Results 101 to 110 of about 270,592 (355)
Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential
Frontiers in PharmacologyMorphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses and poor treatment of pain. Many patients, such as those
Xiangning Zhang +9 more
doaj +1 more source
Causal inference for binary non-independent outcomes [PDF]
arXiv, 2017 Causal inference on multiple non-independent outcomes raises serious challenges, because multivariate techniques that properly account for the outcome's dependence structure need to be considered. We focus on the case of binary outcomes framing our discussion in the potential outcome approach to causal inference.
arxiv
Drug Testing and Analysis, EarlyView.This study is related to the development of a microextraction method for the determination of 56 psychoactive substances in oral fluid. Sample clean‐up is obtained by parallel artificial liquid membrane extraction and analyzed by liquid chromatography–tandem mass spectrometry.
Martina Croce +6 more
wiley +1 more source
Journal of Pharmacy and Pharmacology, 1957 Abstract A series of compounds which antagonise the depressant activity of morphine in dogs is described. The most active compounds are the previously described 2:4-diamino-5-phenylthiazole and tetrahydro-5-aminoacridine. A mixture of both substances is more active than either alone.
F H, SHAW, S, GERSHON, G A, BENTLEY
openaire +2 more sources
Effects of Early-Adolescent, Mid-Adolescent, or Adult Stress on Morphine Conditioned Place Preference [PDF]
, 2015 In light of previous work demonstrating that stress can increase subjective drug reward in adult rats, the present study investigated the influence of stress on morphine conditioned place preference (CPP) in early-adolescent, mid-adolescent, and adult ...
Shields, Chloe
core +1 more source
Infant Death due to Cannabis Ingestion
Drug Testing and Analysis, EarlyView.ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto +9 more
wiley +1 more source
Effects of Testosterone on Analgesia in Formalin-Treated Mice
Journal of Ardabil University of Medical Sciences, 2018 CT Background & objectives: So far, various reports have been presented on the relationship between sex hormones and gender-related differences in pain and analgesia in humans and laboratory animals.
Akram Alijani +3 more
doaj
Amniotic Fluid Ingestion Enhances\ud Opioid-Mediated But Not\ud Nonopioid-Mediated Analgesia [PDF]
, 1990 Ingestion of amniotic fluid or placenta by rats has been shown to enhance several types of opioid-mediated analgesia: that induced by morphine, footshock, vaginal/cervical stimulation, and late pregnancy.
Barton, Debra +2 more
core
Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference [PDF]
, 2014 Learned associations between environmental cues and morphine use play an important role in the maintenance and/or relapse of opioid addiction. Although previous studies suggest that context-dependent morphine treatment alters glutamatergic transmission ...
Al-Hasani, Ream +7 more
core +2 more sources
Drug Testing and Analysis, EarlyView.Close collaboration between an Australian drug checking service and an affiliated university laboratory identifies and characterises the novel synthetic opioid N‐pyrrolidino isotonitazene in an expected oxycodone sample presented by a member of the public.
Blake Curtis +3 more
wiley +1 more source