Results 111 to 120 of about 397,909 (400)
Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia
Frontiers in Neuroscience, 2019 The use of morphine, the standard opioid drug, is limited by its undesirable effects, such as tolerance, physical dependence, and hyperalgesia (increased pain sensitivity).
Bárbara Guimaraes de Freitas +6 more
doaj +1 more source
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction. [PDF]
, 2013 Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic inhibition arising from SNr ...
De-la-Calle-Martin, Adelaida +7 more
core
Morphine-sensitive synaptic transmission emerges in embryonic rat microphysiological model of lower afferent nociceptive signaling [PDF]
, 2021 Kevin Pollard +4 more
openalex +1 more source
The Chemical Record, EarlyView.This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim +4 more
wiley +1 more source
Veterinary Record, EarlyView.Abstract Background In horses, cats and dogs, the opioid butorphanol has been proven effective in management of visceral pain and for peri‐ and postoperative pain relief. The aim of this study was to evaluate physiological responses and indicators of noxious stimuli when adding butorphanol to xylazine for sedation of bull calves during surgical ...
Axel Sannö +3 more
wiley +1 more source
Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential
Frontiers in PharmacologyMorphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses and poor treatment of pain. Many patients, such as those
Xiangning Zhang +9 more
doaj +1 more source
Veterinary Record, EarlyView.Abstract Background Managing open wounds in birds is challenging. This study compared leukocyte‐ and thrombocyte‐rich fibrin (L‐TRF) and autologous grafts for treating wounds in the tarsometatarsus of chickens. Methods Full‐thickness wounds were experimentally induced in the tarsometatarsus of 23 healthy adult chickens.
Vivian Ferreira Rech +6 more
wiley +1 more source
Poultry Science: The effects of the administration of the opioid agonist, morphine, on plasma and tissue concentrations of Met-enkephalin were determined in 14 wk old female chickens.
Colin G. Scanes +1 more
doaj +1 more source
Crystallization and preliminary diffraction studies of morphinone reductase, a flavoprotein involved in the degradation of morphine alkaloids [PDF]
, 1997 Morphinone reductase from Pseudomonas putida M10, a flavoprotein involved in the degradation of morphine alkaloids, was purified from an overexpressing strain of Escherichia coli and crystallized using the hanging-drop vapour-diffusion method ...
Bruce, N C +4 more
core +1 more source
Veterinary Record, EarlyView.Abstract Background Despite common concerns, evidence that anaesthesia impairs vaccine efficacy remains limited. This study assessed the impact of general anaesthesia on the immune response to rabies vaccination in cats. Methods Thirty‐five healthy female cats (6–12 months old) undergoing elective spaying were enrolled.
Pierre Bessière +8 more
wiley +1 more source