Results 1 to 10 of about 145 (112)

The Benzimidazole Derivatives, B1 (N-[(1H-Benzimidazol-2-yl)Methyl]-4-Methoxyaniline) and B8 (N-{4-[(1H-Benzimidazol-2-yl)Methoxy]Phenyl}Acetamide) Attenuate Morphine-Induced Paradoxical Pain in Mice

Frontiers in Neuroscience, 2019
Despite being routinely used for pain management, opioid use is limited due to adverse effects such as development of tolerance and paradoxical pain, including thermal hyperalgesia and mechanical allodynia.
Zahida Idris, Muzaffar Abbas, Humaira Nadeem, Arif-ullah Khan   +3 more
doaj   +3 more sources

Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents.

PLoS ONE
Due to the use of morphine as a well-known analgesic, a semi-synthesis of its newer triazole derivatives was performed in this project. Several derivatives were analyzed via molecular docking and a set of target molecules with acceptable docking scores ...
Faeze Nourmandipour, Reihane Emadi, Peyman Salehi, Mona Kamelan Zargar Zarin, Mona Khoramjouy, Amirreza Dowlati Beirami, Mehrdad Faizi   +6 more
doaj   +4 more sources

Sulfate esters of morphine derivatives: Synthesis and characterization

European Journal of Pharmaceutical Sciences, 2011
Sixteen 3-O- and 6-O-sulfate esters of morphine, codeine and some of their N-methyl quaternary derivatives were synthesized by means of sulfation with pyridine-SO(3) complex and sulfuric acid/N,N'-dicyclohexylcarbodiimide. Complete (1)H- and (13)C-NMR assignments are given for each of the synthesized compounds based on one- and two-dimensional homo ...
András Váradi, András Gergely, Szabolcs Beni   +2 more
exaly   +4 more sources

Synthesis and Modification of Morphine and Codeine, Leading to Diverse Libraries with Improved Pain Relief Properties

Pharmaceutics, 2023
Morphine and codeine, two of the most common opioids, are widely used in the clinic for different types of pain. Morphine is one of the most potent agonists for the μ-opioid receptor, leading to the strongest analgesic effect.
Mona Kamelan Zargar Zarin, Wim Dehaen, Peyman Salehi, Amir Ata Bahmani Asl   +3 more
doaj   +1 more source

Morphine Derivatives with Antianalgesic Action [PDF]

Journal of Pharmacy and Pharmacology, 1954
Summary A series of N-alkyl substituted derivatives of morphine has been synthesised and examined for analgesic and antianalgesic action. Several of these compounds have shown powerful antianalgesic activity, N-propylnormorphine and the diacetyl and dipropionyl derivatives of N-allylnormorphine (nalorphine) being about as active as ...
A F, GREEN, G K, RUFFELL, E, WALTON
openaire   +2 more sources

Design, synthesis, and evaluation of novel racecadotril-tetrazole-amino acid derivatives as new potent analgesic agents

Research in Pharmaceutical Sciences, 2021
Background and purpose: Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse.
Mehdi Asadi, Maryam Mohammadi-Khanaposhtani, Faezeh Sadat Hosseini, Mahdi Gholami, Ahmad Reza Dehpour, Massoud Amanlou   +5 more
doaj   +1 more source

Preparation of polyclonal and monoclonal anti-idiotypic antibodies against morphine-specific immunoglobulins

Медицинская иммунология, 2020
The preparation and study of anti-idiotypic (secondary) antibodies (Ab2) against monoclonal primary antibodies (Ab1) specific to biologically active molecules with a known structure is of great scientific and practical importance.
A. V. Trofimov, V. A. Atanesyan, A. M. Ischenko, E. A. Karabanova, A. Ya. Rak, A. S. Simbirtsev, N. B. Gamaleya, A. G. Berzina, N. V. Stankova, G. D. Kapanadze, L. I. Ulyanova, T. A. Klimova   +11 more
doaj   +1 more source

Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue

Pharmacology Research & Perspectives, 2023
The opioid epidemic has impacted over 10 million Americans in 2019. Opioids, like morphine, bind non‐selectively in both peripheral tissue, leading to effective pain relief, and central tissue, resulting in dangerous side effects and addiction.
Makena Augenstein, Nayiri Alexander, Matthew Gartner   +2 more
doaj   +1 more source

How μ-opioid receptor recognizes fentanyl

Nature Communications, 2021
Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear.
Quynh N. Vo, Paween Mahinthichaichan, Jana Shen, Christopher R. Ellis   +3 more
doaj   +1 more source

X.—Researches on the polymerides of morphine and their derivatives [PDF]

J. Chem. Soc., 1873
n ...
Mayer, E. Ludwig, Wright, C. R. A.
openaire   +2 more sources