Results 11 to 20 of about 11,589 (292)

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies [PDF]

Journal of Medicinal Chemistry, 2018
Opioids, like morphine, are the mainstay analgesics for the treatment and control of pain. Despite this, they often exhibit severe side effects that limit dose; patients often become tolerant and dependent on these drugs, which remains a major health concern. The analgesic actions of opioids are primarily mediated via the μ-opioid receptor, a member of
Raymond Lam, Arisbel B. Gondin, Meritxell Canals, Barrie Kellam, Stephen J. Briddon, Bim Graham, Peter J. Scammells   +6 more
openaire   +3 more sources

High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors

Molecular Pain, 2009
Background Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic.
Messlinger Karl, Reeh Peter W, Forster Alexander B, Fischer Michael JM   +3 more
doaj   +4 more sources

PREPARATION AND PROPERTIES OF MURINE ANTI-IDIOTYPIC MONOCLONAL ANTIBODIES RECOGNIZING PRIMARY RABBIT POLYCLONAL ANTIBODIES AGAINST MORPHINE DERIVATIVES

Медицинская иммунология, 2019
Anti-idiotypic antibodies (Ab2), according to the network theory of Jerne, are second-generation immunoglobulins that are produced against the idiotype of an antibody to a specific antigen.
A. V. Trofimov, A. M. Ischenko, A. Ya. Rak, V. E. Sergeeva, A. S. Simbirtsev, N. B. Gamaleya, A. G. Berzina, N. V. Stankova, L. I. Ulyanova, T. A. Klimova   +9 more
doaj   +3 more sources

Review of Structural Modification and Development of Novel Tramadol Derivatives [PDF]

Molecules
Tramadol acts via μ-opioid receptor agonism and monoamine reuptake inhibition but is clinically limited by metabolic dependence, interindividual variability, and addiction risks. Structural modification aims to resolve these limitations.
Ni Wang, Xiaoli Zhou, Jingwen Wang, Lixin Sun, Bo Liu, Lihui Yin   +5 more
doaj   +2 more sources

Pharmacological investigations of N-substituent variation in morphine and oxymorphone: opioid receptor binding, signaling and antinociceptive activity. [PDF]

PLoS ONE, 2014
Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain.
Tanila Ben Haddou, Szabolcs Béni, Sándor Hosztafi, Davide Malfacini, Girolamo Calo, Helmut Schmidhammer, Mariana Spetea   +6 more
doaj   +2 more sources

Detection and accumulation of morphine in hair using GC–MS

Egyptian Journal of Forensic Sciences, 2016
Background: The detection of drugs ingested by humans by analyzing hair samples for their presence is now one of the imperative techniques in the field of forensic toxicology.
Himanshu Khajuria, Biswa Prakash Nayak
doaj   +2 more sources

Therapeutic Update in Neonatal Opioid Withdrawal Syndrome: Comparative Effectiveness of Pharmacological Treatments and the ESC Assessment Model. A Systematic Review [PDF]

Health Science Reports
The number of newborns with neonatal opioid withdrawal syndrome is alarming, due to the increase in maternal opioid use. Despite the critical health and socio‐economic impact, a precise clinical and therapeutic approach for opioid using infants and ...
José Miguel Pérez‐Jiménez, Marta Periañez Langa, Manuel Coheña Jimenez   +2 more
doaj   +2 more sources

Impacts of morphine addiction on spermatogenesis in rats

Iranian Journal of Reproductive Medicine, 2016
Background: There are numerous investigations on wide range of issues that disrupt regulatory spermatogenesis, individuals who are exposed to drug abuse faced infertility and immature spermatogenesis. Objective: The aim of this study was to evaluate the
Nasrin Takzare, Esmaeil Samizadeh, Saeed Shoar, Masoumeh Majidi Zolbin, Mohammad Naderan, Ali Lashkari, Azam Bakhtiarian   +6 more
doaj   +1 more source

Prevalence, detection, symptoms of intoxication and treatment of new fentanyl analogue overdose with cyklopropylfentanyl (MAF) as an example

Alcoholism and Drug Addiction, 2022
The mortality rate attributable to new fentanyl analogue intoxication is a serious issue in various regions, especially in the U.S. In Poland, there have been poisonings reported since 2014 as regards these substances.
Sylwia Fudalej
doaj   +1 more source

Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. [PDF]

PLoS ONE, 2012
To enhance the drug-like properties of the endogenous opioid peptide endomorphin-1 (1 = Tyr-Pro-Trp-Phe-NH(2)), the N-terminus of the peptide was modified with 2-aminodecanoic acid, resulting in compound 3.
Pegah Varamini, Friederike M Mansfeld, Joanne T Blanchfield, Bruce D Wyse, Maree T Smith, Istvan Toth   +5 more
doaj   +1 more source