Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants
Molecules, 2020 Vaccination could be a promising alternative warfare against drug addiction and abuse. For this purpose, so-called haptens can be used. These molecules alone do not induce the activation of the immune system, this occurs only when they are attached to an
István Köteles +4 more
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Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice. [PDF]
PLoS ONE, 2016 Citrus Bergamia Risso, commonly known as Bergamot, is a fruit whose Essential Oil and Bergamot Polyphenolic Fraction have numerous medicinal properties.
Filomena Lauro +11 more
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Molecules, 2022 The μ-opioid receptors belong to the family of G protein-coupled receptors (GPCRs), and their activation triggers a cascade of intracellular relays with the final effect of analgesia.
Dominik Straszak +8 more
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Diels–Alder Adducts of Morphinan-6,8-Dienes and Their Transformations
Molecules, 2022 6,14-ethenomorphinans are semisynthetic opiate derivatives containing an ethylene bridge between positions 6 and 14 in ring-C of the morphine skeleton that imparts a rigid molecular structure.
János Marton +5 more
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Pharmacology of Morphine and its Derivatives [PDF]
Proceedings of the Royal Society of Edinburgh, 1891 It is necessary for a clear understanding of the chemical changes which occur on treating morphine in various ways, and for comparing its physiological action with that of the bodies so formed, that we should summarise at some length the exact position of our present knowledge regarding its chemistry and pharmacology.Morphine has the composition ...
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Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest
ChemistryOpen, 2019 This review focuses on recent developments in the physicochemical profiling of morphine and other opioids. The acid‐base properties and lipophilicity of these compounds is discussed at the microscopic, species‐specific level.
Prof. Károly Mazák +2 more
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MORPHINE AND OTHER PHENANSHRENE DERIVATIVES [PDF]
The Journal of Nervous and Mental Disease, 1903 n ...
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Chronic paternal morphine exposure increases sensitivity to morphine-derived antinociception [PDF]
, 2021 Abstract Parental exposure to drugs of abuse such as opioids can have profound and long-lasting effects on reward processing and drug sensitivity across generations. However, little is known about the impact of long-term paternal exposure to morphine on offspring sensitivity to morphine-derived antinociception during painful experiences.
Andre B. Toussaint +12 more
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Computational Design of β-Fluorinated Morphine Derivatives for pH-specific Binding
, 2021 Molecular extension and dissection techniques are used to design a morphine derivative that promotes selective binding in inflamed tissue due to its lower pH while avoiding dangerous activation in the brain. Morphine is used to treat pain associated with
Augenstein, Makena +2 more
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Evaluation of Analgesic Activity of Newly Synthesized Phthalyl- tyrosyl-glycin Sodium
Iraqi Journal of Pharmaceutical Sciences, 2017 Alteration in the backbone structure of the endogenously released opioid peptides Leu5/Met5 enkephalins may result in compounds having comparable profile of pharmacological activity but with different physicochemical properties and side effects. Phthalyl
Muthanna S. AL-Taee +2 more
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