Results 31 to 40 of about 11,589 (292)

Forensic Application of Genetic and Toxicological Analyses for the Identification and Characterization of the Opium Poppy (Papaver somniferum L.)

Biology, 2022
Background: A reliable and science-based taxonomic determination of Papaver somniferum L. (opium poppy), the illegal species of the genus Papaver, may have practical and legal implications for law enforcement. P.
Roberta Tittarelli, Angelo Gismondi, Gabriele Di Marco, Federico Mineo, Francesca Vernich, Carmelo Russo, Luigi Tonino Marsella, Antonella Canini   +7 more
doaj   +1 more source

Preparation of benzoate esters of morphine and its derivatives

, 2012
Sustained analgesia is crucial for patients suffering from long-acting pain. Ester derivatives of morphine could enhance the lipophilicity of morphine; consequently its transdermal delivery as well as its duration of action are also increased. Therefore,
Hosztafi, Sándor, Noszál, Béla, Tóth, Gergő, Béni, Szabolcs   +3 more
core   +1 more source

Effect of different doses of intrathecal morphine on postoperative fentanyl consumption in open live donor hepatectomy – A double-blind, randomized controlled trial

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Intrathecal morphine (ITM) has been widely used to provide effective postoperative analgesia. This study aims to compare the efficacy and safety of three different doses of ITM – 200, 300, and 400 μg – in patients undergoing open ...
Gaurav Sindwani, Sooraj Desai, Udit Dhingra, Ankit Bharadwaj, Viniyendra Pamecha, Mahesh K. Arora   +5 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

, 2017
Morphine derivatives displaying a mixed MOR/DOR biological characteristic were synthesized through a one-pot multicomponent approach.
Jay P. McLaughlin, Michelle R. Hoot, Margret Cazares, Yongping Yu, Colette T. Dooley, Marc A. Giulianotti, Michelle L. Ganno, Shainnel O. Eans, Richard A. Houghten, Jiaan Shao   +9 more
core   +1 more source

Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon

Molecules, 2019
Here, we report a convenient synthetic procedure for the preparation of four novel indanyl carbanucleoside derivatives in the racemic form. The action of these compounds against hepatitis C virus was evaluated in vitro using the replicon cell line, Huh7 ...
Matías E. Gómez, Emiliano A. Gentile, M. Florencia Martini, María L. Cuestas, Verónica L. Mathet, Graciela Y. Moltrasio, Albertina G. Moglioni   +6 more
doaj   +1 more source

Editorial Commentary: The Pericapsular Nerve Group Block in Hip Arthroscopy: Not a Miracle—But Ignoring It Is No Longer an Option

Arthroscopy, EarlyView.
Abstract Postoperative pain control remains a central determinant of discharge readiness, patient satisfaction, and opioid exposure after hip arthroscopy. Even modest improvements in early analgesia can meaningfully influence recovery pathways.
Alexander Zimmerer
wiley   +1 more source

Perioperative Intravenous Dexamethasone Improves Pain and Functional Outcomes After Arthroscopic Rotator Cuff Repair

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the effect of perioperative dexamethasone on patient‐reported pain, functional outcomes, and minimal clinically important difference (MCID) achievement following arthroscopic rotator cuff repair. Methods Patients who underwent rotator cuff repair between 2013 and 2023 were identified and divided into groups.
Trevor D. Wolterink, Germain Craddock, Joshua P. Castle, Michael A. Gaudiani, Chimdindu Obinero, Alexander S. Jurayj, Christian A. Freitag, Nathan Y. Li, Jared Mahylis, Stephanie J. Muh   +9 more
wiley   +1 more source

Unveiling the superior analgesic: Thoracic epidural versus intrathecal morphine in open live donor hepatectomy – A randomized controlled trial

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Postoperative pain management in open live donor hepatectomy is vital. This study aimed to compare postoperative analgesia provided by intrathecal morphine (ITM) and epidural in open live donor hepatectomy.
Rohit Saini, Gaurav Sindwani, Neha Garg, Mahesh K. Arora, Viniyendra Pamecha, Nihar Mohapatra   +5 more
doaj   +1 more source

Evaluation the Variation of Morphine Percentage in Different Turkish Opium Poppy (Papaver somniferum L.) Lines in Three Years [PDF]

Journal of Medicinal Plants and By-products, 2015
Opium poppy (Papaver somniferum L.) has two major products: alkaloids in the capsules and the seeds. It is known that opium poppy today contains alkaloid in great quantities.
Amir Rahimi, Neşet Arslan, Negar Valizadeh   +2 more
doaj