Results 51 to 60 of about 11,589 (292)
British Journal of Clinical Pharmacology, EarlyView.Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf +6 more
wiley +1 more source
Stereoselective morphine-like discriminative properties of a new alkylaminonaphthalenic derivative
, 2000 The morphine-like properties of a series of aminoalkyl- and cycloalkylamino-naphtalenic derivatives of 17-methyl-17-azaequilenine were studied in rats trained to discriminate morphine (5.6 mg/kg IP) from vehicle in a two-lever operant behavioral ...
Sabina Fraioli +2 more
core +1 more source
Molecules, 2020 In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties.
Jolanta Dyniewicz +5 more
doaj +1 more source
Precision medicine in paediatrics: Progress and priorities
British Journal of Clinical Pharmacology, EarlyView.Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain +3 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2020 Background: Applicants for marriage in Iran must undergo mandatory screening tests for substance abuse before the wedding. The aim of this study was to determine the prevalence rate of substance abuse in applicants for marriage in Isfahan Province from ...
Reza Khadivi +2 more
doaj +1 more source
Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children
British Journal of Clinical Pharmacology, EarlyView.Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley +1 more source
The analgesic effect of narcotic herbal remedies [PDF]
Herba PolonicaPain is one of the most common symptoms that lead people to seek medical attention. In standard medical practice, a patient's well-being depends on pain relief.
Mateusz Gutowski +7 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian +4 more
wiley +1 more source
The morphine and aporphine alkaloids [PDF]
, 1929 VOLUME. 1: Published papers1. The morphine group. Part 1. || 2. The morphine group. Part 2. || 3. The constitution of codeineand thebaine. || 4. Synthetical experiments in the naphthyridine groups. || 5. Derivatives of homocatechol.
Gulland, John Masson
core
Asian Pacific Journal of Cancer Biology, 2019 Drug abuse remains a serious health and social threat in the world. According to the United Nations Office of Drugs and Crime (UNODC) 1n 2010, an estimated 16.5 million people use opium or its derivatives illicitly (1). Meanwhile, Iran has the first rank
Hossein Ghahremani +2 more
doaj +1 more source