Results 61 to 70 of about 11,589 (292)

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, EarlyView.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source

Synthetic compounds patterned after morphine alkaloids

, 1940
Relationships between chemical constitution and pharmacological action of morphine, phenanthrene, dibenzofuran, and carbazole derivatives have been discussed;The preparations of some dibenzofuran derivatives, particularly those containing nitrogen, have ...
Cook, Thomas
core   +1 more source

Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. [PDF]

, 1992
Loperamide, an opiate agonist of high specificity for p-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing’s disease. However, there is little information on
Pfeiffer, M., Lange, M., Auernhammer, Christoph J., Stalla, G.K., Müller, O.A.   +4 more
core   +1 more source

Fentanyl and its derivatives: Pain-killers or man-killers?

Heliyon
Fentanyl is a synthetic μ-opioid receptor agonist approved to treat severe to moderate pain with faster onset of action and about 100 times more potent than morphine.
Jiri Patocka, Wenda Wu, Patrik Oleksak, Romana Jelinkova, Eugenie Nepovimova, Lenka Spicanova, Pavlina Springerova, Suliman Alomar, Miao Long, Kamil Kuca   +9 more
doaj   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Evaluation of Analgesic Activities of Tremetone Derivatives Isolated from the Chilean Altiplano Medicine

Natural Product Communications, 2012
Parastrephia lepidophylla , family Asteraceae, has ancient use in traditional medicine in the region of Tarapacá, Chile. Bioguided fractionation of extracts of this plant was undertaken in the search for compounds with analgesic and antioxidant activity.
Julio Benites, Eunices Gutierrez, José López, Mauricio Rojas, Leonel Rojo, Maria do Céu Costa, Maria Pilar Vinardell, Pedro Buc Calderon   +7 more
doaj   +1 more source

Bioresearch of New 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones

Molecules, 2020
The subject of the work was the synthesis of new derivatives of1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione with potential analgesic and sedative activity. Eight compounds werereceived.
Dominika Szkatuła, Edward Krzyżak, Szczepan Mogilski, Jacek Sapa, Barbara Filipek, Piotr Świątek   +5 more
doaj   +1 more source

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Effect of naloxone-3-glucuronide and N-methylnaloxone on the motility of the isolated rat colon after morphine [PDF]

, 2007
The effect of the opioid antagonists naloxone-3-glucuronide and N-methylnaloxone on rat colon motility after morphine stimulation was measured. The rat model consisted of the isolated, vascularly perfused colon. The antagonists (10(-4) M, intraluminally)
Netzer, Peter, Reber, Peter, Scheurer, Ulrich, Batista, Catarina, Brenneisen, Rudolf, Flogerzi, Beatrice   +5 more
core   +1 more source

Intramolecular carbonickelation of alkenes

Beilstein Journal of Organic Chemistry, 2013
The efficiency of the intramolecular carbonickelation of substituted allylic ethers and amines has been studied to evaluate the influence of the groups borne by the double bond on this cyclization. The results show that when this reaction takes place, it
Rudy Lhermet, Muriel Durandetti, Jacques Maddaluno   +2 more
doaj   +1 more source