Results 11 to 20 of about 303,149 (361)

Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers

CPT: Pharmacometrics & Systems Pharmacology, 2022
Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access.
Thomas Duflot, Tony Pereira, Marie‐Pierre Tavolacci, Robinson Joannidès, Frédéric Aubrun, Fabien Lamoureux, Virginie Eve Lvovschi   +6 more
doaj   +1 more source

Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism

Pharmacology Research & Perspectives, 2023
Morphine induces spinal 5‐hydroxytryptamine (5‐HT) release, but the role and mechanism of the spinal 5‐HT release induced by morphine are not well understood.
Shingo Nakamura, Shuji Komatsu, Toshihiko Yamada, Hiromi Kitahara, Tatsuo Yamamoto   +4 more
doaj   +1 more source

Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]

Reviews in Clinical Medicine, 2015
Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar, Golnaz Vaseghi, Mahmoud Rafieian-Kopaei, Sasan Andalib, Azadeh Eshraghi, Nooshin Masoudian   +5 more
doaj   +3 more sources

Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring

Journal of Biomedical Science, 2009
Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring.
Tao Pao-Luh, Chen Jain-Fang, Wu Ling-Yi, Huang Eagle   +3 more
doaj   +1 more source

THE TREATMENT OF MORPHINISM. [PDF]

The Lancet, 1909
n ...
Sainsbury, Harrington, Jennings, Oscar
openaire   +5 more sources

Morphine Nitrate and Morphine Acetate**Scientific Section at Detroit. [PDF]

The Journal of the American Pharmaceutical Association (1912), 1915
n ...
Engelhardt, H., Winters, O. E.
openaire   +2 more sources

Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]

, 2015
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad, A Fugelstad, Abi Lyndon, AJ Ruttenber, Anne Lingford-Hughes, AR Lingford-Hughes, B Levine, BM Mathers, CA Paronis, Chris Bailey, CK Kuo, CN Lessov, CP Bailey, CP Bailey, CP Bailey, E Kelly, E Valjent, Eamonn Kelly, EB Rex, EJ Waite, F Chen, FL Smith, FL Smith, Graeme Henderson, GS Ling, H Sakakibara, HW Matthes, HY Lin, I Rodriguez-Martin, J Llorente, J McPherson, J Reneau, JM White, Joanne Roberts, John MacLachlan, JT Williams, JW Lewis, KL McGilliard, L He, LC Hull, LC Saland, LJ Sim-Selley, LM Bohn, LQ Hong-Brown, M Aliczki, M Hickman, M Hickman, M Inoue, M Pierce, Matthew Hickman, N Quillinan, NG Shah, R Cornish, R Romberg, Rob Hill, S Darke, S Darke, S Kishioka, Sarah Withey, SJ Slater, SV Dighe, TC Green, Yvonne Kershaw   +62 more
core   +3 more sources

Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study [PDF]

, 2015
© 2015 Asian Pacific Society of Respirology. Background and objective The management of chronic refractory breathlessness is one of the indications for regular low-dose (≤30 mg/24 h) oral sustained release morphine.
Abernethy, Amy P., Currow, David, Currow, David C., Eckert, Danny J., Johnson, Miriam J., Martins, Rodrigo T., Toson, Barbara   +6 more
core   +1 more source

Role of Pharmacokinetic Effects in the Potentiation of Morphine Analgesia by L-Type Calcium Channel Blockers in Mice

Journal of Pharmacological Sciences, 2004
The present study was designed to investigate the pharmacokinetic interaction of morphine with three classes of L-type calcium channel blockers (CCB) and its relationship to morphine-induced mechanical antinociception in mice.
Norifumi Shimizu, Shiroh Kishioka, Takehiko Maeda, Yohji Fukazawa, Chizuko Yamamoto, Masanobu Ozaki, Hiroyuki Yamamoto   +6 more
doaj   +1 more source

Intrathecal morphine plus general anesthesia in cardiac surgery: effects on pulmonary function, postoperative analgesia, and plasma morphine concentration

Clinics, 2009
OBJECTIVES: To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac surgery. INTRODUCTION: Lung dysfunction increases morbidity and mortality after cardiac surgery.
Luciana Moraes dos Santos, Verônica Cavani Jorge Santos, Silvia Regina Cavani Jorge Santos, Luiz Marcelo Sá Malbouisson, Maria José Carvalho Carmona   +4 more
doaj   +1 more source