Results 11 to 20 of about 339,726 (399)

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +3 more sources

Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference [PDF]

Journal of Neuroscience, 2014
Learned associations between environmental cues and morphine use play an important role in the maintenance and/or relapse of opioid addiction. Although previous studies suggest that context-dependent morphine treatment alters glutamatergic transmission ...
Al-Hasani, Ream, Bruchas, Michael R, Fakira, Amanda K, Gonzalez-Romero, Jose L, McCall, Jordan G, Melyan, Zare, Moron, Jose A, Portugal, George S   +7 more
core   +3 more sources

3‐[3‐(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone‐derived novel class of MOR‐antagonists

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco, Antonio Laus, Maksims Vanejevs, Anastasija Ture, Rafaela Mostallino, Nicholas Pintori, Maria Antonietta De Luca, M. Paola Castelli, Gaetano Di Chiara   +8 more
wiley   +1 more source

Perineuronal morphine: a comparison with epidural morphine [PDF]

Anaesthesia, 1988
SummaryIn a double‐blind, randomised controlled cross‐over study the effects of perineuronal (perifemoral) injections of morphine were compared with epidural injections with the same amount of morphine in patients after knee surgery. Better pain scores were achieved during treatment with epidural morphine.
H.V. Johannsen, E. Kristoffersen, J. J. Daugaard, J. B. Dahl, J. A. Dahl   +4 more
openaire   +3 more sources

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley   +1 more source

Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]

Reviews in Clinical Medicine, 2015
Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar, Golnaz Vaseghi, Mahmoud Rafieian-Kopaei, Sasan Andalib, Azadeh Eshraghi, Nooshin Masoudian   +5 more
doaj   +3 more sources

Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils. [PDF]

PLoS ONE, 2010
BACKGROUND: Mammalian cells synthesize morphine and the respective biosynthetic pathway has been elucidated. Human neutrophils release this alkaloid into the media after exposure to morphine precursors.
Elise Glattard, Ingeborg D Welters, Thomas Lavaux, Arnaud H Muller, Alexis Laux, Dan Zhang, Alexander R Schmidt, François Delalande, Benoît-Joseph Laventie, Sylvie Dirrig-Grosch, Didier A Colin, Alain Van Dorsselaer, Dominique Aunis, Marie-Hélène Metz-Boutigue, Francis Schneider, Yannick Goumon   +15 more
doaj   +1 more source

Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers

CPT: Pharmacometrics & Systems Pharmacology, 2022
Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access.
Thomas Duflot, Tony Pereira, Marie‐Pierre Tavolacci, Robinson Joannidès, Frédéric Aubrun, Fabien Lamoureux, Virginie Eve Lvovschi   +6 more
doaj   +1 more source

Phase Retrieval and Design with Automatic Differentiation [PDF]

, 2021
The principal limitation in many areas of astronomy, especially for directly imaging exoplanets, arises from instability in the point spread function (PSF) delivered by the telescope and instrument. To understand the transfer function, it is often necessary to infer a set of optical aberrations given only the intensity distribution on the sensor - the ...
arxiv   +1 more source

Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism

Pharmacology Research & Perspectives, 2023
Morphine induces spinal 5‐hydroxytryptamine (5‐HT) release, but the role and mechanism of the spinal 5‐HT release induced by morphine are not well understood.
Shingo Nakamura, Shuji Komatsu, Toshihiko Yamada, Hiromi Kitahara, Tatsuo Yamamoto   +4 more
doaj   +1 more source