Results 71 to 80 of about 397,909 (400)

In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]

, 2018
Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta, Negri, Lucia, Rief, Silvia, Schmidhammer, Helmut, Spetea, Mariana.   +4 more
core   +2 more sources

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Sentience in cephalopod molluscs: an updated assessment

Biological Reviews, EarlyView.
ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell, Heather Browning, Andrew Crump, Charlotte C. Burn, Jonathan Birch   +4 more
wiley   +1 more source

The Effect of Memory Reinforcement by Cholinergic Agonist and Music on Creating Morphine Dependency in Mice Using Conditioned Place Preference (CPP) Method

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
The most important side effect of addictive drugs is their interaction with nervous system so that soon after taking the drug, the neurons̉ connections in nervous system are addicted to receiving the drugs frequently. The aim of this study was the effect
Eebrahim Hosseini, Mokhtar Mokhtari, Akbar Vahdati, Neamat Razmi, Farnaz Tavakoli   +4 more
doaj  

Early‐Life Clinical Factors Shape Cerebellar Structure in Preterm‐Born Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Preterm birth alters typical brain development due to complex exposures related to neonatal illness, pain management, and brain injury. Despite an increased understanding of neonatal brain injury on developmental outcomes, the association of cerebellar maturation with school‐age motor and cognitive function remains incompletely ...
Victoria Rapos, Steven Ufkes, Cecil Chau, Jessie van Dyk, Ting Guo, Ruth E. Grunau, Steven P. Miller   +6 more
wiley   +1 more source

Opiate Drug Seeking and Addiction: The Influence of Sucrose Consumption on the Acquisition and Expression of Morphine-induced Conditioned Place Preferences (CPP) [PDF]

, 2019
Sucrose intake may lead to changes in brain and behavior similar to the effects of abused drugs. For example, sucrose may agonize endogenous opiate systems and modulate opiate-seeking behavior.
Bakner, Lee, Berger, Isabel R., Senthithasan, Shareeta, Wolff, Stephanie   +3 more
core   +1 more source

Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: Implications for the study of the affective properties of drugs of abuse [PDF]

, 2013
Several studies suggest that 50-kHz ultrasonic vocalizations (USVs) may indicate a positive affective state in rats, and these vocalizations are increasingly being used to investigate the properties of psychoactive drugs.
FRAU L, MORELLI M, PLUMITALLO A, SIMOLA N   +3 more
core   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

The gamma-aminobutyric acid type B (GABA_B) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

Behavioral and Brain Functions, 2012
Background Repeated morphine exposure can induce behavioral sensitization. There are evidences have shown that central gamma-aminobutyric acid (GABA) system is involved in morphine dependence.
Fu Zhenyu, Yang Hongfa, Xiao Yuqiang, Zhao Gang, Huang Haiyan   +4 more
doaj   +1 more source

Unbearable Pain: India's Obligation to Ensure Palliative Care [PDF]

, 2009
This 102-page report found that many major cancer hospitals in India do not provide patients with morphine, despite the fact that more than 70 percent of their patients are incurable and likely to require pain treatment and palliative care.

core