Results 71 to 80 of about 235,160 (357)

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

Annals of Neurology, EarlyView.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim, Manyoel Lim, Thiago D. Nascimento, Frank Porreca, Robert A. Koeppe, Nouchine Hadjikhani, Alexandre F. DaSilva   +6 more
wiley   +1 more source

The Effect of Memory Reinforcement by Cholinergic Agonist and Music on Creating Morphine Dependency in Mice Using Conditioned Place Preference (CPP) Method

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
The most important side effect of addictive drugs is their interaction with nervous system so that soon after taking the drug, the neurons̉ connections in nervous system are addicted to receiving the drugs frequently. The aim of this study was the effect
Eebrahim Hosseini, Mokhtar Mokhtari, Akbar Vahdati, Neamat Razmi, Farnaz Tavakoli   +4 more
doaj  

Morphinism in Children. [PDF]

JAMA: The Journal of the American Medical Association, 1895
Brooklyn, N. Y., Feb. 1, 1895. To the Editor: —I am desirous of adding to the clinical literature of morphinism in children. If any reader of yourJournalhas noted a case, and will furnish me details, I will appreciate the favor and give full credit.
openaire   +2 more sources

Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial

Canadian Medical Association Journal, 2014
Background: Recent warnings from Health Canada regarding codeine for children have led to increased use of nonsteroidal anti-inflammatory drugs and morphine for common injuries such as fractures.
N. Poonai, G. Bhullar, K. Lin, Adam Papini, D. Mainprize, J. Howard, J. Teefy, M. Bale, Cindy Langford, R. Lim, L. Stitt, M. Rieder, Samina Ali   +12 more
semanticscholar   +1 more source

Comparison between Acute and Long-Term Effects of Verapamil on Naloxane Induced Morphine Withdrawal in Mice

Journal of Research in Medical Sciences, 2004
Background: There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of Morphine dependence. Objective: To investigate the acute and long-term effects of Verapamil in Morphine dependent mice.
M Rabbani, A Jafarian, M Sobhanian
doaj  

The gamma-aminobutyric acid type B (GABA_B) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

Behavioral and Brain Functions, 2012
Background Repeated morphine exposure can induce behavioral sensitization. There are evidences have shown that central gamma-aminobutyric acid (GABA) system is involved in morphine dependence.
Fu Zhenyu, Yang Hongfa, Xiao Yuqiang, Zhao Gang, Huang Haiyan   +4 more
doaj   +1 more source

Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish

Frontiers in Microbiology, 2020
Morphine is one of the most severely abused drugs in the world. Previous research on morphine addiction has focused on the central nervous system (CNS). Studies have shown that a two-way regulation of the brain and gut microbiota (GM), suggesting a link ...
Zhu Chen, Chen Zhijie, Zhou Yuting, Xiao Shilin, Zhou Qichun, Ou Jinying, Luo Chaohua, Li Jing, Mo Zhixian   +8 more
doaj   +1 more source

The use of international classification of diseases codes to identify hospital admissions linked with adverse drug events: Validation study

British Journal of Clinical Pharmacology, EarlyView.
Aims Several methods exist to identify hospital admissions related to adverse drug events (ADEs). Clinical adjudication by healthcare professionals is the gold standard but is labour‐intensive. Spontaneous reporting and routinely collected healthcare data using a set of International Classification of Diseases (ICD) codes often underestimate the ...
Zuzana Juhásová, Fatma Karapinar‐Çarkit, Daniala L. Weir   +2 more
wiley   +1 more source

The Role of Spinal PKCγ in Tolerance and Hyperalgesia Induced by Repeated Morphine Administration in Male Rats

Iranian South Medical Journal, 2018
Background: The aim of this study was to investigate the possible role of Protein Kinase Cᵧ (PKCᵧ) in morphine tolerance and induced hyperalgesia following repeated morphine administration in male rats.  Material and Methods: Rats were divided into
Kobra Ghasemloo, Homa Manaheji, Lila Dargahi, Sareh pandamooz   +3 more
doaj