Assessing the 2004-2018 fentanyl misusing issues reported to an international range of adverse reporting systems [PDF]
© 2019 Schifano, Chiappini, Corkery and Guirguis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania +3 more
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Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad +62 more
core +3 more sources
Evaluation of the Effects of Ketorolac on Tolerance and Dependence to Morphine in Male Mice
Introduction: According to the high prevalence of pathologic and physiologic dependence to morphine as a strong opioid analgesics and tolerance to analgesic effects, it seems inevitable to find solutions to reduce these consequences.
Mahdieh Anoush, Maryam Afroogh
doaj
Dose-dependency of intra-articular morphine analgesia
We have examined if the analgesic effects of intra-articular morphine are dose-dependent in patients undergoing elective arthroscopic knee surgery. At the end of surgery, patients were allocated randomly to one of four groups to receive intra-articular saline (n = 22), or morphine 1 mg (n = 24), 2 mg (n = 21) or 4 mg (n = 19). After operation, patients
R, Likar +4 more
openaire +2 more sources
Sumatriptan effects on morphine-induced antinociceptive tolerance and physical dependence: The role of nitric oxide [PDF]
Sumatriptan, a 5HT (5-hydroxytryptamine)1B/1D receptor agonist, showed neuroprotection in different studies. The aim of the present study was to investigate the effect of sumatriptan on morphine-induced antinociceptive tolerance and physical dependence.
Akbarian, Reihaneh. +8 more
core
Pharmacogenetics of analgesic drugs [PDF]
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R +4 more
core +1 more source
Does Morphine Exposure Before Gestation Change Anxiety-Like Behavior During Morphine Dependence in Male Wistar Rats? [PDF]
Sabzevari S +5 more
europepmc +1 more source
Micturition in naive and morphine‐dependent rats [PDF]
Voiding responses were recorded in conscious water-loaded rats. Morphine sulphate (5 mg kg-1) elevated the volume threshold for micturition (MV); the group mean MV of 16 rats after morphine was 40% larger than control. Micturition was nevertheless complete since no urine remained in the bladder afterwards.
openaire +2 more sources
Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring [PDF]
[[abstract]]Background: Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring.
Pao-Luh Tao +2 more
core +1 more source
Cortical pain responses in human infants [PDF]
Despite the recent increase in our understanding of the development of pain processing, it is still not known whether premature infants are capable of processing pain at a cortical level.
Boyd, S +6 more
core +1 more source

