Results 111 to 120 of about 51,793 (252)

Endoscopic‐Assisted Peri‐Root Anesthesia Provides Superior Intraoperative Analgesia Over Epidural Anesthesia in L5–S1 Interlaminar Endoscopic Discectomy

Orthopaedic Surgery, EarlyView.
The endoscopic‐assisted peri‐root anesthesia technique demonstrates superior intraoperative analgesic efficacy and a better safety profile compared to conventional epidural anesthesia in Delta large‐channel interlaminar endoscopic discectomy. This surgeon‐administered technique enhances patient comfort and procedural safety.
Hengrui Chang, Yuanqing Niu, Yiwen Zhang, Qi'ao Wu, Jiayuan Sun, Di Zhang, Jiaxin Xu   +6 more
wiley   +1 more source

Role of Orexin in the Tolerance and Physical Dependence to Morphine

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2014
BACKGROUND AND OBJECTIVE: Although opioid drugs cause analgesia and more effective in treatment of pain but, its utility is hindered by the development of tolerance to its analgesic effects.
Samad Nazemi, Hassan Azhdari zarmrhri, Hashem Haghdoost-Yazdi   +2 more
doaj  

Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats

Neural Plasticity, 2009
Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane. Given that microinjection of morphine into the PAG produces antinociception, it is hypothesized that the movement of DORs to the membrane will
Michael M. Morgan, Michelle D. Ashley, Susan L. Ingram, MacDonald J. Christie   +3 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Effect of intrauterine morphine sulfate exposure on cerebellar histomorphological changes in neonatal mice [PDF]

, 2011
Neurotoxic effects of morphine sulfate in adult cerebellar cortex and neonatal cerebral cortex have been studied in animal models. This study was done to determine the neurotoxic effects of prenatal morphine exposure on the histo morphological changes of
Ghafari, S., Golalipour, M.J., Roshandel, D.   +2 more
core  

Transaminase and Norcoclaurine Synthase One‐Pot Cascades Towards (1S)‐Tetrahydroisoquinolines

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
A TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Jianxiong Zhao, Yeke Ni, Yu Wang, John M. Ward, Jack W. E. Jeffries, Helen C. Hailes   +5 more
wiley   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 869-878, March 2026.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source

The Association Between Partner Reactions to Chronic Pain and Pain‐Related Outcomes: A Systematic Review

European Journal of Pain, Volume 30, Issue 3, March 2026.
ABSTRACT Background and Objective It has long been recognised that the social context, including partner relationships, can impact the chronic pain experience and pain outcomes. The goal of this systematic review is to analyse, appraise and integrate the current evidence regarding the relationships between partner reactions to chronic pain behaviours ...
G. F. Donohue, P. J. Meredith, J. Strong, L. Page, N. E. Andrews   +4 more
wiley   +1 more source

Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva, Maria Gabriely de Lima Silva, Eduardo S. Silva, Lucas Yure S. Silva, Renata Torres Pessoa, Silvio C. Alves‐Júnior, Jullyana S. S. Quintans, Laurent Picot, Irwin Rose A. Menezes, Lucindo J. Quintans‐Júnior   +9 more
wiley   +1 more source

Upregulation of μ-Opioid Receptor in the Rat Spinal Cord Contributes to the α2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain

Journal of Pain Research, 2020
Pinyi Zhang,1 Jianlong Bu,2 Xiaohong Wu,1 Lin Deng,1 Meng Chi,1 Chao Ma,3 Xiaoding Shi,1 Guonian Wang3 1Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Thoracic Surgery ...
Zhang P, Bu J, Wu X, Deng L, Chi M, Ma C, Shi X, Wang G   +7 more
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