Results 121 to 130 of about 685,770 (240)

Vitex agnus-castus fruit extract restrains acquisition and expression of morphine-induced tolerance in mice [PDF]

, 2016
Tolerance to the analgesic effect of opioids is the major concern of long-term administration of these compounds. In this study, the effects of hydroalcoholic extract of Vitex agnus-castus (VAC) on the acquisition and expression of morphine-induced ...
Saberi, M., Ghorbani, M., Chavooshi, B., Saberi, F.   +3 more
core  

Opioid Use and Family Members' Experiences of Opioids in Paediatric Cancer Pain Management: An Integrative Review

Scandinavian Journal of Caring Sciences, Volume 40, Issue 4, December 2026.
ABSTRACT Aim To analyse the use of opioids in children with cancer and the experiences of their family members regarding opioids used in pain management to improve family nursing. Design An integrative review. Methods A systematic literature search was carried out in four databases (CINAHL, MEDLINE, PsycInfo and Scopus) in August 2023, and was ...
Noora Puusa, Eeva Harju, Maija‐Liisa Kalliomäki, Elina Haavisto   +3 more
wiley   +1 more source

Effects of Caffeine on Morphine Tolerance and Analgesia in Mice: Caffeine attenuates morphine effects

, 2011
Caffeine, an adenosine A1, A2A, and A2B receptor antagonist, is frequently used as an adjuvant analgesic in combination with non steroidal anti-inflammatory drugs or opioids. The aim of this study was to evaluate the effects of caffeine on preventing the
Reza Abdelalipur, Mehrdad Shahidi, Bohloul Habibi Asl   +2 more
core   +1 more source

Postoperative Pain Treatment After Pancreatic Surgery: A Systematic Review With Meta‐Analyses and Trial Sequential Analyses

European Journal of Pain, Volume 30, Issue 10, November 2026.
ABSTRACT Background Major pancreatic surgery is associated with significant postoperative pain that impairs early mobilisation and recovery. ERAS guidelines for pancreaticoduodenectomy recommend multimodal opioid‐sparing analgesia, with a strong recommendation for epidural analgesia and continuous wound infiltration as an alternative.
Caroline D. Lassen, Fatieh Yousef, Eske Kvanner Aasvang, Waqas Farooqui, Sermed Ellebæk Nicolae, Anja Geisler   +5 more
wiley   +1 more source

Naringenin may prevent morphine-induced tolerance via inhibiting glycogen synthase kinase-3beta activity in mice [PDF]

Journal of Medicinal Plants
Background: Opioids are essential for pain treatment, but their long-term usage results in tolerance. Naringenin, a natural flavonoid found in fruit, inhibits the enzyme that causes opioid tolerance, making it effective in treating neurodegenerative ...
Samira Shirooie, Seyed Kimia Jasemi, Golale Babaei, Mohammad Reza Morovati, Maryam Ghanbari-Movahed, Saman Barzegar, Mohammad Hosein Farzaei   +6 more
doaj  

Protective effect of telmisartan against morphine-induced analgesic tolerance in mice

: Morphine tolerance is a serious clinical problem characterized by a decreased analgesic effect resulted from the long-term use of morphine with uncertain etiology and therapeutic interventions are limited.
ENGİN, SEÇKİN, Kaya-Yasar, Yesim, GÜN, ELİF, BARUT, ELİF NUR, DUMAN, MİNE   +4 more
core   +1 more source

Clinical outcomes of a novel flowable calcium silicate cement in equine endodontic treatment

Equine Veterinary Journal, Volume 58, Issue 6, Page 1602-1611, November 2026.
Abstract Background Orthograde endodontic treatment of equine cheek teeth is performed infrequently with variable success rates of obturation with calcium hydroxide paste (CHP). A novel flowable calcium silicate cement (eCSC) formulated for use as an obturation material in equine teeth has demonstrated acceptable canal filling volumes and evidence of ...
Kirsten Jackson, Josephine Faulkner, Carsten Staszyk, William Ha, Ebony Quintrell, Erin Kelty   +5 more
wiley   +1 more source

Effectiveness of immersive virtual reality‐based interventions for alleviating peri‐ and post‐procedural pain and anxiety in gynecologic settings: A systematic review and meta‐analysis of randomized controlled trials

International Journal of Gynecology &Obstetrics, Volume 175, Issue 2, Page 565-583, November 2026.
Abstract Background Non‐pharmacological and complementary therapeutic, notably immersive virtual reality‐based interventions (IVR), could alleviate pain and anxiety associated with gynecologic procedures. Objective To evaluate the effectiveness of IVR in reducing peri‐ and post‐procedural pain and anxiety in gynecologic procedures.
Cristina González‐Lara, Marina Piñar‐Lara, Esteban Obrero‐Gaitán, Héctor García‐López, Irene Cortés‐Pérez   +4 more
wiley   +1 more source

Studies on behavioral regulations of morphine tolerance in rats

, 2007
Opioids remain the drugs of choice in chronic pain treatment, but opioid tolerance, defined as a decrease in analgesic effect after prolonged or repeated use, dramatically limits their clinical utility.
Xu, Jijun
core   +1 more source

Liproxstatin‑1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death

, 2019
Morphine tolerance is a classic, challenging clinical issue. However, the mechanism underlying this phenomenon remains poorly understood. Recently, studies have shown that ferroptosis correlates with drug resistance.
Li Wan, Xuhui Chen, Miaomiao Feng, Xuhui Chen (7862075), Bo Zhang (6559), Chuanhan Zhang (7862081), Yue Zhang (30585), Li Wan (11826), Wenlong Yao (1314561), Tongtong Liu, Bo Zhang, Miaomiao Feng (7862078), Tongtong Liu (2553457), Yue Zhang, Chuanhan Zhang, Wenlong Yao   +15 more
core   +1 more source