Results 141 to 150 of about 52,092 (254)

Evaluation of Therapeutic Opioids in Skin‐Derived Matrices (Sweat and Sebum) of Neonatal and Pediatric Patients and Their Role in Opioid Incorporation Into Hair

Drug Testing and Analysis, Volume 18, Issue 4, Page 561-571, April 2026.
Concentration ranges, dose–concentration relationships, and metabolite‐to‐parent drug ratios of therapeutic opioids were evaluated in hair and skin swab samples of 150 pediatric patients. Skin‐derived matrices such as sweat or sebum were shown to contribute to analyte incorporation into hair in a systematic manner.
Max Polke, Florian Zapf, Julia T. Scherer, Clarissa D. Voegel, Tanja Restin, Marc W. Schmid, Thomas Kraemer, Tina M. Binz   +7 more
wiley   +1 more source

Naringenin may prevent morphine-induced tolerance via inhibiting glycogen synthase kinase-3beta activity in mice [PDF]

Journal of Medicinal Plants
Background: Opioids are essential for pain treatment, but their long-term usage results in tolerance. Naringenin, a natural flavonoid found in fruit, inhibits the enzyme that causes opioid tolerance, making it effective in treating neurodegenerative ...
Samira Shirooie, Seyed Kimia Jasemi, Golale Babaei, Mohammad Reza Morovati, Maryam Ghanbari-Movahed, Saman Barzegar, Mohammad Hosein Farzaei   +6 more
doaj  

Alpha Oscillations and Conditioned Pain Modulation Is Associated With Treatment Resistance to Spinal Cord Stimulation for Neuropathic Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background Neuropathic pain (NP) is a severe form of chronic pain associated with reduced quality of life. Spinal cord stimulation (SCS) can provide pain relief for some but not all treated, highlighting the importance of predictive markers.
Rima El‐Sayed, Vaidhehi Veena Sanmugananthan, Ariana Besik, Natalie Rae Osborne, Emily Paige Mills, Camille Fauchon, Anuj Bhatia, Benjamin T. Dunkley, Karen Deborah Davis   +8 more
wiley   +1 more source

Pain Medicine and the Opioid Crisis: Time to Own Our Responsibility!

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Pain remains a major unmet health need. Rising opioid prescribing has not reduced population pain and has directly contributed to increased morbidity and mortality. Opioid use disorder (OUD) and pain frequently coexist. Many people with OUD experience acute and chronic pain and a substantial proportion of patients prescribed opioids develop ...
Duncan Ritchie, Patrice Forget
wiley   +1 more source

Phytochemistry and Bioactivities of Thymol and Carvacrol: Molecular Pathways, Metabolism, and Therapeutic Insights

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Thymus serpyllum (wild thyme) contains bioactive compounds such as carvacrol, thymol, β‐caryophyllene, γ‐terpinene, and α‐thujene, along with essential vitamins and minerals. These constituents exhibit antioxidant, antimicrobial, anti‐inflammatory, and antidiabetic activities.
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Farhang Hameed Awlqadr, Hassan Raza, Shehnshah Zafar, Aimen Mazhar, Duaa Tariq, Muhammed Noori Saeed, Khaled Arab   +8 more
wiley   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

AAKD: A standardized and comprehensive acupuncture anesthesia knowledge platform for enhanced recovery after surgery and mechanism

VIEW, Volume 7, Issue 2, April 2026.
Acupuncture anesthesia (AA) is an application of acupuncture innovation in surgical operations, combined with anesthetic techniques, and is a model of integrated Chinese and Western medicine. We proposed the Acupuncture Anesthesia Knowledge Database (AAKD), in which all data have been meticulously curated by field experts and assessed by a multi ...
Ying Wang, Honglian Huang, Chenchen Feng, Xueli Zhang, Weiting Wang, Ziyi Wei, Jing Li, Xintong Yu, Hanzhi Lu, Chunfang Gao, Ke Wang, Jia Zhou   +11 more
wiley   +1 more source

Upregulation of miR-375 level ameliorates morphine analgesic tolerance in mouse dorsal root ganglia by inhibiting the JAK2/STAT3 pathway

Journal of Pain Research, 2017
Haiqin Li, Rong Tao, Jing Wang, Lingjie Xia Department of Clinical Pain, The People’s Hospital of Henan Province, Zhengzhou, People’s Republic of China Abstract: Several lines of evidence indicate that microRNAs (miRNAs ...
Li HQ, Tao R, Wang J, Xia LJ
doaj  

Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice. [PDF]

J Tradit Chin Med, 2023
Shuai H, Hua M, Tingting J, Rubing Y, Ziyi W, Jie Z, Jianwen S, Yongxin L.   +7 more
europepmc   +1 more source

Association Between American Society of Anesthesiologists Physical Status Classification System and Remimazolam Sedation Outcomes

Academic Emergency Medicine, Volume 33, Issue 4, April 2026.
ABSTRACT Background Remimazolam (RM) is an ultrashort‐acting benzodiazepine with pharmacodynamic properties ideal for procedural sedation in emergency departments (EDs). This study evaluated the safety of RM when used for procedural sedation of American Society of Anesthesiologists (ASA) I–III patients in the ED. Aims To compare the occurrence of no or
Caroline H. Brynning, Simone P. Busch, Anne L. Krarup, Dorte Melgaard   +3 more
wiley   +1 more source