Results 141 to 150 of about 23,947 (195)

Tolerance to Drugs, especially to Morphine

Nature, 1960
VARIOUS theories have been put forward to elucidate the development of tolerance to a drug. For example, it has been observed by Zauder1 that “as tolerance develops (in the rat), the amount of morphine appearing in the urine decreases”. This was in accordance with Gross and Thomson's observations on the dog2. Cochin et al.
G, NADEAU, G, SOBOLEWSKI
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Morphine tolerance in hepatic cirrhosis

Gastroenterology, 1961
Summary Electroencephalogram (EEG) recordings were made in 32 subjects on 36 occasions before administration of 8 mg. or 16 mg. of morphine subcutaneously, and 3 hours thereafter. The method of measuring and grading the EEG response is described. Eight mg.
J, LAIDLAW, A E, READ, S, SHERLOCK
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Morphine: Single-Dose Tolerance

Science, 1968
Rats show a significant degree of tolerance to a second dose of morphine, with the degree of tolerance increasing the longer the delay between the two doses of morphine. To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.
C, Kornetsky, G, Bain
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Dependence in the absence of tolerance to morphine

European Journal of Pharmacology, 1984
Intravenous morphine depressed the firing of cat dorsal horn neurones to impulses in unmyelinated primary afferents. Electrophoretic administration of naloxone in the substantia gelatinosa between 10 min and 6 h after morphine revealed hyper-responsiveness which was not associated with apparent tolerance to morphine.
S M, Johnson, A W, Duggan
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Binding of Morphine in Tolerant Rats

British Journal of Addiction to Alcohol & Other Drugs, 1968
SummaryThe proportion of bound morphine: [100 (total‐free morphine): (total morphine)] in the liver and of free morphine in the blood of tolerant rats receiving a lethal dose of morphine by intravenous infusion at 1, 3, 8 and 16 days after withdrawal were studied. The results were compared with those obtained in two groups of non‐tolerant controls. One
A, Penna-Herreros, L, Tampier, E, Sanchez   +2 more
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Prolactin analgesia: Tolerance and cross-tolerance with morphine

European Journal of Pharmacology, 1985
The development of acute tolerance to prolactin-induced analgesia in mice was identified by using the writhing test. This tolerance was antagonised by naltrexone pretreatment indicating a role of an opioid mechanism. Cross-tolerance between morphine and prolactin was observed with regard to analgesia.
S, Ramaswamy, S, Viswanathan, J S, Bapna
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The effect of pentobarbital on the antinociceptive action of morphine in morphine-tolerant and non-tolerant rats

Life Sciences, 1979
Abstract The interaction of sodium pentobarbital with morphine sulfate in both morphine-tolerant and non-tolerant rats was investigated using the tail-compression test for analgesia. Male Sprague-Dawley rats (300–350 g) were given pentobarbital (4, 8, or 16 mg/kg) 5 min before morphine (2, 4, 6, or 8 mg/kg).
E B, Geller, L, Durlofsky, A, Cowan, C, Harakal, M W, Adler   +4 more
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Formation of Morphine Tolerance in Offspring of Morphine-Tolerant Animals: Neurochemical and Neuroimmune Correlates

Bulletin of Experimental Biology and Medicine, 2001
We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in ...
S V, Litvinova, V V, Aristova, V V, Shul'govskii, L A, Basharova, N N, Terebilina, L F, Panchenko   +5 more
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Morphine as a cue in associative tolerance to morphine's analgesic effects

Pharmacology Biochemistry and Behavior, 1993
This study examined the extent to which low doses of morphine paired explicitly with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test.
A, Cepeda-Benito, S T, Tiffany
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Influence of antineoplastic drugs on morphine analgesia and on morphine tolerance

European Journal of Pharmacology, 1999
The possible influence of cisplatin, methotrexate, adriamycin and vincristine on thermal pain threshold, morphine analgesia and development of morphine tolerance was investigated in mice. In the hot-plate test, the nociceptive threshold was not affected by acute or repeated administration of any of the antineoplastic drugs used.
GENEDANI, Susanna, M. Bernardi, BERTOLINI, Alfio   +2 more
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