Results 151 to 160 of about 52,092 (254)

Morphine-Induced Analgesic Tolerance Effect on Gene Expression of the NMDA Receptor Subunit 1 in Rat Striatum and Prefrontal Cortex

Basic and Clinical Neuroscience, 2016
Introduction: Morphine is a potent analgesic but its continual use results in analgesic tolerance. Mechanisms of this tolerance remain to be clarified.
Shamseddin Ahmadi, Fatemeh Rafieenia, Jalal Rostamzadeh   +2 more
doaj  

AT1R in Central Nervous System Disorders: Unveiling Novel Mechanisms and Therapeutic Avenues for Addiction

Addiction Biology, Volume 31, Issue 4, April 2026.
AT1R signaling drives addiction through interconnected pathways, and AT1R antagonists target multiple nodes for therapeutic effects. ABSTRACT Although the angiotensin II type 1 receptor (AT1R), a pivotal component of the renin–angiotensin system (RAS), is associated with cardiovascular and renal homeostasis, burgeoning evidence implicates its critical ...
Jianan Lv, Dan Zhu, Sisi Song, Jiahui Zhou, Xiaoyu Zhang, Wenhua Zhou, Yu Liu, Zizhen Si   +7 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Integrating gepants into clinical practice for the acute treatment of migraine

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 976-989, April 2026.
Abstract Objective To assess the role of small‐molecule calcitonin gene–related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments. Background Triptans have established efficacy and are widely prescribed for the acute treatment of migraine.
Richard B. Lipton, David W. Dodick, Linda Davis, Stephanie J. Nahas, Peter J. Goadsby   +4 more
wiley   +1 more source

Partial tarsal arthrodesis with plate fixation for management of traumatic tarsometatarsal injuries in five cats

Journal of Small Animal Practice, Volume 67, Issue 4, Page 353-358, April 2026.
Objectives To describe the aetiology, presentation, complications and outcome in cats with traumatic injuries of the tarsometatarsal joint treated with partial tarsal arthrodesis. Materials and Methods Retrospective series of five client‐owned cats. Medical records were retrieved for cats with traumatic injuries of the tarsometatarsal joint treated ...
R. L. Nixon, D. N. Clements, J. M. Ryan
wiley   +1 more source

Endoscopic‐Assisted Peri‐Root Anesthesia Provides Superior Intraoperative Analgesia Over Epidural Anesthesia in L5–S1 Interlaminar Endoscopic Discectomy

Orthopaedic Surgery, Volume 18, Issue 4, Page 815-823, April 2026.
The endoscopic‐assisted peri‐root anesthesia technique demonstrates superior intraoperative analgesic efficacy and a better safety profile compared to conventional epidural anesthesia in Delta large‐channel interlaminar endoscopic discectomy. This surgeon‐administered technique enhances patient comfort and procedural safety.
Hengrui Chang, Yuanqing Niu, Yiwen Zhang, Qi'ao Wu, Jiayuan Sun, Di Zhang, Jiaxin Xu   +6 more
wiley   +1 more source

The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray. [PDF]

J Neuroinflammation, 2022
Ouyang H, Zhang J, Chi D, Zhang K, Huang Y, Huang J, Huang W, Bai X.   +7 more
europepmc   +1 more source

Co-Administration of nalbuphine to improve morphine tolerance in mice with bone cancer pain. [PDF]

Mol Pain, 2023
Ren B, Zhang J, Yang X, Sun D, Sheng D, Fang Q, Ji Z.   +6 more
europepmc   +1 more source

Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance. [PDF]

J Clin Invest, 2023
Jiao Y, Gao P, Dong L, Ding X, Meng Y, Qian J, Gao T, Wang R, Jiang T, Zhang Y, Kong D, Wu Y, Chen S, Xu S, Tang D, Luo P, Wu M, Meng L, Wen D, Wu C, Zhang G, Shi X, Yu W, Rong W.   +23 more
europepmc   +1 more source

The role of nucleus accumbens dopamine signaling in the development of morphine tolerance in neuropathic pain. [PDF]

Korean J Pain
Cui S, Kim WM, Jang EA, Lee YJ, Kang DH, Lee HG, Choi JI.   +6 more
europepmc   +1 more source