Results 151 to 160 of about 23,947 (195)
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Morphine tolerance and sensitization in the Hamster
Pharmacology Biochemistry and Behavior, 1985The effects of morphine on hamster locomotor activity were studied. Repeated administration of morphine in doses from 5 to 40 mg/kg produced systematic changes in morphine's biphasic time effect pattern: morphine's sedative effects decreased (tolerance) while morphine's excitatory effects increased (sensitization).
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The Journal of Pharmacology and Experimental Therapeutics, 1997
The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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Absence of Cross-Tolerance to Heroin in Morphine-Tolerant Mice
Science, 1980Mice implanted with morphine pellets demonstrated a 30-fold increase in tolerance to subcutaneously administered morphine but showed no cross-tolerance to subcutaneously administered heroin. When given morphine intracerebroventricularly, the mice showed no tolerance to morphine or cross-tolerance to heroin.
D G, Lange +3 more
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Cross-tolerance to cannabinoids in morphine-tolerant rhesus monkeys
Psychopharmacology, 2015Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects limit their use. Therapeutic utility might be improved by combining opioids with other drugs to enhance analgesic effects, but only if adverse effects are not similarly changed.Cannabinoids have been shown to enhance the antinociceptive potency of opioids ...
L R, Gerak +3 more
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Tolerance to morphine analgesia
Pain Forum, 1999There is a growing body of evidence that implicates the role of excitatory amino acids (EEAs), in particular the N-methyl-D-aspartate (NMDA) receptor, in the development of opioid tolerance. In their Focus article, Fundytus and Coderre have proposed a model of opioid tolerance that highlights the importance of metabotropic glutamate receptors (MGIuRs ...
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Tolerance to morphine stimulus control: role of morphine maintenance dose
Psychopharmacology, 1990Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery.
A M, Young +5 more
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Tolerance develops to spinal morphine analgesia but not morphine-induced convulsions
European Journal of Pharmacology, 1990Administration of morphine into the spinal intrathecal (i.t.) space produced dose-dependent analgesia in the mouse. At higher doses i.t. morphine induced seizures of the hindlimbs. Mice treated chronically with morphine (75 mg pellet, s.c.) for 72 h were tolerant to the analgesic effects of i.t. morphine, but not to the proconvulsant action.
B C, Yoburn +3 more
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Role of Endothelin in Neonatal Morphine Tolerance
Journal of Cardiovascular Pharmacology, 2004Management of neonatal opioid tolerance and withdrawal symptoms remains a major challenge in neonatal intensive care units. We provide evidence that central endothelin (ET) mechanisms are involved in the development of morphine tolerance in neonatal rats.
Bhagya L, Puppala +3 more
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Cross-Tolerance between Ethanol and Morphine
1980Adult male Wistar rats were fed chronically a liquid diet providing 35% of the calories as ethanol (10-12 g/kg ethanol daily), while pair-fed controls received the corresponding diet with alcohol replaced by an equicaloric concentration of sucrose. Rectal temperatures, after test doses of ethanol or morphine, were measured in several groups of rats at ...
A D, Lê +3 more
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Influence of Cocarboxylase on Tolerance to Morphine in the Rat
Nature, 1958THE basic physiological mechanism affected by morphine may be that of the enzymatic processes involved in glucose metabolism: it is known, indeed, that morphine inhibits glucose and pyruvic acid utilization by minced brain1, and the decarboxylation by rabbit's liver and brain homogenates of pyruvic acid2.
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