Results 171 to 180 of about 685,770 (240)

The cannabinoid CB₂ agonist LY2828360 suppresses neuropathic pain behavior and attenuates morphine tolerance and conditioned place preference in rats. [PDF]

Neuropharmacology
Guenther KG, Wirt JL, Oliva I, Saberi SA, Crystal JD, Hohmann AG.   +5 more
europepmc   +1 more source

Conditioned morphine tolerance promotes neurogenesis, dendritic remodelling and pro-plasticity molecules in the adult rat hippocampus. [PDF]

Addict Biol
Nejad GG, Mottarlini F, Tavassoli Z, Caffino L, Fumagalli F, Homberg JR, Fathollahi Y.   +6 more
europepmc   +1 more source

Blocking Palmitoylation of Apelin Receptor Alleviates Morphine Tolerance in Neuropathic Cancer Pain. [PDF]

Int J Biol Sci
Fan X, Gong M, Zhang S, Niu W, Sun S, Yu H, Chen X, Fang Z.   +7 more
europepmc   +1 more source

The Melatonin Type 2 Receptor Agonist IIK7 Attenuates and Reverses Morphine Tolerance in Neuropathic Pain Rats Through the Suppression of Neuroinflammation in the Spinal Cord. [PDF]

Pharmaceuticals (Basel)
Kuthati Y, Wong CS.
europepmc   +1 more source

Ferroptosis inhibitor ferrostatin-1 attenuates morphine tolerance development in male rats by inhibiting dorsal root ganglion neuronal ferroptosis. [PDF]

Korean J Pain
Dirik H, Taşkıran AŞ, Joha Z.
europepmc   +1 more source

Biasing G<i>βγ</i> Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State. [PDF]

Mol Pharmacol
Sanchez GA, Smrcka AV, Jutkiewicz EM.
europepmc   +1 more source

Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study. [PDF]

Front Microbiol
Han S, Gao J, Wang Z, Xiao Y, Ge Y, Liang Y, Gao J.   +6 more
europepmc   +1 more source

Cannabinoid CB₂ receptors in primary sensory neurons are implicated in CB₂ agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance. [PDF]

Biomed Pharmacother
Guenther KG, Lin X, Xu Z, Makriyannis A, Romero J, Hillard CJ, Mackie K, Hohmann AG.   +7 more
europepmc   +1 more source

Morphine Tolerance Is Attenuated in Germfree Mice and Reversed by Probiotics, Implicating the Role of Gut Microbiome

Proceedings of the National Academy of Sciences of the United States of America, 2019
Prolonged exposure to opioids results in analgesic tolerance, drug overdose, and death. The mechanism underlying morphine analgesic tolerance still remains unresolved. We show that morphine analgesic tolerance was significantly attenuated in germfree (GF)
Jingjing Meng, Irina Fernandez, Yuguang J Ban   +2 more
exaly   +2 more sources

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Tolerance to Electroacupuncture and Its Cross Tolerance to Morphine

Neuropharmacology, 1981
Abstract Electroacupuncture (EA) applied to both legs of the rat for 30 min (1session) raised the average tail flick latency to 89% above the control level. Repeated electroacupuncture for 6 sessions, with 30 min between successive sessions, resulted in a gradual decline in the hypoalgesic effect.
Han Jisheng, J S Han
exaly   +3 more sources