Results 181 to 190 of about 685,770 (240)
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Morphine Metabolism and Morphine Tolerance in Goldfish
Anesthesiology, 1970Tolerance to morphine was induced in goldfish shown to be unable to metabolize morphine. Ability to metabolize is, therefore not a prercquisite to development of tolerance.
G A, Jansen, N M, Greene
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Morphine-Induced Attenuation of Morphine Tolerance
Science, 1981Rats experienced both morphine and an environmental cue, but the cue always signaled a drug-free period. They were subsequently administered morphine in the presence of the cue, and the development of analgesic tolerance was assessed. The prior experience retarded such tolerance.
S, Siegel, R E, Hinson, M D, Krank
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Attenuation of Morphine Analgesic Tolerance by Rosuvastatin in Naïve and Morphine Tolerance Rats
Inflammation, 2014Recent studies suggested that statins have anti-inflammatory effects beyond their lipid-lowering properties. Since inflammation in the central nervous system was highly related to morphine tolerance, we sought to investigate whether statins could affect morphine tolerance by mediating glia-derived proinflammatory cytokines secretion. We have undertaken
Yongle, Li +5 more
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The development of tolerance to morphine in the rat
Psychopharmacology, 1977Tolerance to various effects of morphine in the rat can be quantified by means of a shift of semi-logarithmic dose-response curves. Tolerance to analgesia (hot plate, acetic acid writhing), catalepsy, and the tilted plane develops in a closely similar manner.
M, Fernandes, S, Kluwe, H, Coper
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GABA in morphine analgesia and tolerance
Life Sciences, 1985Drugs affecting various steps of GABA transmission exhibit analgesia in a variety of experimental models in animals; this analgesic response generally requires high doses of the drugs and does not appear to be opiate-like since the GABAergic analgesia is naloxone-insensitive and lacks dependence liability.
S P, Sivam, I K, Ho
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Tolerance to Drugs, especially to Morphine
Nature, 1960VARIOUS theories have been put forward to elucidate the development of tolerance to a drug. For example, it has been observed by Zauder1 that “as tolerance develops (in the rat), the amount of morphine appearing in the urine decreases”. This was in accordance with Gross and Thomson's observations on the dog2. Cochin et al.
G, NADEAU, G, SOBOLEWSKI
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Morphine tolerance in hepatic cirrhosis
Gastroenterology, 1961Summary Electroencephalogram (EEG) recordings were made in 32 subjects on 36 occasions before administration of 8 mg. or 16 mg. of morphine subcutaneously, and 3 hours thereafter. The method of measuring and grading the EEG response is described. Eight mg.
J, LAIDLAW, A E, READ, S, SHERLOCK
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Brain Research, 1987
The acquisition and retention of tolerance to the antinociceptive effect of supraspinal morphine on the tail withdrawal reflex was assessed in rats implanted with unilateral cannulae in the periaqueductal gray (PAG). Development of tolerance to daily microinjections of morphine was indicated by the return of the tail flick response within 4 days ...
Judith A Siuciak, C Advokat
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The acquisition and retention of tolerance to the antinociceptive effect of supraspinal morphine on the tail withdrawal reflex was assessed in rats implanted with unilateral cannulae in the periaqueductal gray (PAG). Development of tolerance to daily microinjections of morphine was indicated by the return of the tail flick response within 4 days ...
Judith A Siuciak, C Advokat
exaly +3 more sources
Morphine: Single-Dose Tolerance
Science, 1968Rats show a significant degree of tolerance to a second dose of morphine, with the degree of tolerance increasing the longer the delay between the two doses of morphine. To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.
C, Kornetsky, G, Bain
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Dependence in the absence of tolerance to morphine
European Journal of Pharmacology, 1984Intravenous morphine depressed the firing of cat dorsal horn neurones to impulses in unmyelinated primary afferents. Electrophoretic administration of naloxone in the substantia gelatinosa between 10 min and 6 h after morphine revealed hyper-responsiveness which was not associated with apparent tolerance to morphine.
S M, Johnson, A W, Duggan
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