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Molecular basis of morphine tolerance

open access: yesJapanese Journal of Pharmacology, 2000
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Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance

European Journal of Pharmacology, 1988
The influence of calcium channel blockers on morphine-induced analgesia and on tolerance to the chronic administration of the opiate was investigated in mice. The effects of a test dose of morphine were significantly increased by the administration of diltiazem, flunarizine, nicardipine and verapamil.
E, Contreras, L, Tamayo, M, Amigo
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