Results 191 to 200 of about 685,770 (240)
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Binding of Morphine in Tolerant Rats
British Journal of Addiction to Alcohol & Other Drugs, 1968SummaryThe proportion of bound morphine: [100 (total‐free morphine): (total morphine)] in the liver and of free morphine in the blood of tolerant rats receiving a lethal dose of morphine by intravenous infusion at 1, 3, 8 and 16 days after withdrawal were studied. The results were compared with those obtained in two groups of non‐tolerant controls. One
A, Penna-Herreros +2 more
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Prolactin analgesia: Tolerance and cross-tolerance with morphine
European Journal of Pharmacology, 1985The development of acute tolerance to prolactin-induced analgesia in mice was identified by using the writhing test. This tolerance was antagonised by naltrexone pretreatment indicating a role of an opioid mechanism. Cross-tolerance between morphine and prolactin was observed with regard to analgesia.
S, Ramaswamy, S, Viswanathan, J S, Bapna
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Life Sciences, 1979
Abstract The interaction of sodium pentobarbital with morphine sulfate in both morphine-tolerant and non-tolerant rats was investigated using the tail-compression test for analgesia. Male Sprague-Dawley rats (300–350 g) were given pentobarbital (4, 8, or 16 mg/kg) 5 min before morphine (2, 4, 6, or 8 mg/kg).
E B, Geller +4 more
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Abstract The interaction of sodium pentobarbital with morphine sulfate in both morphine-tolerant and non-tolerant rats was investigated using the tail-compression test for analgesia. Male Sprague-Dawley rats (300–350 g) were given pentobarbital (4, 8, or 16 mg/kg) 5 min before morphine (2, 4, 6, or 8 mg/kg).
E B, Geller +4 more
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Bulletin of Experimental Biology and Medicine, 2001
We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in ...
S V, Litvinova +5 more
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We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in ...
S V, Litvinova +5 more
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Morphine as a cue in associative tolerance to morphine's analgesic effects
Pharmacology Biochemistry and Behavior, 1993This study examined the extent to which low doses of morphine paired explicitly with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test.
A, Cepeda-Benito, S T, Tiffany
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Influence of antineoplastic drugs on morphine analgesia and on morphine tolerance
European Journal of Pharmacology, 1999The possible influence of cisplatin, methotrexate, adriamycin and vincristine on thermal pain threshold, morphine analgesia and development of morphine tolerance was investigated in mice. In the hot-plate test, the nociceptive threshold was not affected by acute or repeated administration of any of the antineoplastic drugs used.
GENEDANI, Susanna +2 more
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Morphine tolerance and sensitization in the Hamster
Pharmacology Biochemistry and Behavior, 1985The effects of morphine on hamster locomotor activity were studied. Repeated administration of morphine in doses from 5 to 40 mg/kg produced systematic changes in morphine's biphasic time effect pattern: morphine's sedative effects decreased (tolerance) while morphine's excitatory effects increased (sensitization).
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The Journal of Pharmacology and Experimental Therapeutics, 1997
The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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Absence of Cross-Tolerance to Heroin in Morphine-Tolerant Mice
Science, 1980Mice implanted with morphine pellets demonstrated a 30-fold increase in tolerance to subcutaneously administered morphine but showed no cross-tolerance to subcutaneously administered heroin. When given morphine intracerebroventricularly, the mice showed no tolerance to morphine or cross-tolerance to heroin.
D G, Lange +3 more
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Cross-tolerance to cannabinoids in morphine-tolerant rhesus monkeys
Psychopharmacology, 2015Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects limit their use. Therapeutic utility might be improved by combining opioids with other drugs to enhance analgesic effects, but only if adverse effects are not similarly changed.Cannabinoids have been shown to enhance the antinociceptive potency of opioids ...
L R, Gerak +3 more
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