Results 191 to 200 of about 52,092 (254)
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Morphine-Induced Attenuation of Morphine Tolerance
Science, 1981Rats experienced both morphine and an environmental cue, but the cue always signaled a drug-free period. They were subsequently administered morphine in the presence of the cue, and the development of analgesic tolerance was assessed. The prior experience retarded such tolerance.
S, Siegel, R E, Hinson, M D, Krank
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Morphine: Single-Dose Tolerance
Science, 1968Rats show a significant degree of tolerance to a second dose of morphine, with the degree of tolerance increasing the longer the delay between the two doses of morphine. To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.
C, Kornetsky, G, Bain
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Morphine Metabolism and Morphine Tolerance in Goldfish
Anesthesiology, 1970Tolerance to morphine was induced in goldfish shown to be unable to metabolize morphine. Ability to metabolize is, therefore not a prercquisite to development of tolerance.
G A, Jansen, N M, Greene
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Morphine tolerance in hepatic cirrhosis
Gastroenterology, 1961Summary Electroencephalogram (EEG) recordings were made in 32 subjects on 36 occasions before administration of 8 mg. or 16 mg. of morphine subcutaneously, and 3 hours thereafter. The method of measuring and grading the EEG response is described. Eight mg.
J, LAIDLAW, A E, READ, S, SHERLOCK
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Prolactin analgesia: Tolerance and cross-tolerance with morphine
European Journal of Pharmacology, 1985The development of acute tolerance to prolactin-induced analgesia in mice was identified by using the writhing test. This tolerance was antagonised by naltrexone pretreatment indicating a role of an opioid mechanism. Cross-tolerance between morphine and prolactin was observed with regard to analgesia.
S, Ramaswamy, S, Viswanathan, J S, Bapna
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The Journal of Pharmacology and Experimental Therapeutics, 1997
The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance
Pain, 2005Pain sensitivity reflects a balance between pain facilitatory and inhibitory systems. To characterize the relationships between these systems we examined the interactions between the analgesic effects of morphine and the anti-analgesic effects of the pro-inflammatory cytokine interleukin-1 (IL-1).
Yehuda, Shavit +4 more
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Attenuation of Morphine Analgesic Tolerance by Rosuvastatin in Naïve and Morphine Tolerance Rats
Inflammation, 2014Recent studies suggested that statins have anti-inflammatory effects beyond their lipid-lowering properties. Since inflammation in the central nervous system was highly related to morphine tolerance, we sought to investigate whether statins could affect morphine tolerance by mediating glia-derived proinflammatory cytokines secretion. We have undertaken
Yongle, Li +5 more
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Tolerance to electroacupuncture and its cross tolerance to morphine
Neuropharmacology, 1981Abstract Electroacupuncture (EA) applied to both legs of the rat for 30 min (1session) raised the average tail flick latency to 89% above the control level. Repeated electroacupuncture for 6 sessions, with 30 min between successive sessions, resulted in a gradual decline in the hypoalgesic effect.
J S, Han, S J, Li, J, Tang
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Morphine tolerance and naloxone receptor binding
Life Sciences, 1975Abstract 3H-naloxone specific binding studies have confirmed the induction of receptor expansion after an acute injection of morphine, as reported by Pert et al (3) as well as the lack of expansion in chronically morphinized rats shown by Klee and Streaty (4) using dihydromorphine.
J, Harris, D T, Kazmierowski
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