Results 211 to 220 of about 52,092 (254)
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Cross-Tolerance between Ethanol and Morphine
1980Adult male Wistar rats were fed chronically a liquid diet providing 35% of the calories as ethanol (10-12 g/kg ethanol daily), while pair-fed controls received the corresponding diet with alcohol replaced by an equicaloric concentration of sucrose. Rectal temperatures, after test doses of ethanol or morphine, were measured in several groups of rats at ...
A D, Lê +3 more
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Morphine‐3‐glucuronide prevents tolerance to morphine‐6‐glucuronide in mice
European Journal of Pain, 1997Daily subcutaneous (s.c.) pretreatment with morphine‐3‐glucuronide (6 mg/kg) was found to reduce morphine‐6‐glucuronide (4 mg/kg s.c.)‐induced antinociception, with no decrease in the effect over 5 days. Morphine‐6‐glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine‐3‐glucorinide pretreatment, results in a significant increase in ...
Faura, Clara C. +2 more
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Extinction of morphine analgesic tolerance
Learning and Motivation, 1980Abstract It has been suggested that the analgesic effect of morphine becomes attenuated over the course of successive administrations by a conditional, compensatory, hyperalgesic response elicited by the administration procedure, thus accounting (in part) for analgesic tolerance.
Shepard Siegel +2 more
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Peripheral morphine analgesia resistant to tolerance in chronic morphine-treated mice
Neuroscience Letters, 1999Intraplantarly (i.pl.)-injected morphine showed a peripheral analgesia in experiments to assess the blockade of bradykinin (i.pl.)-induced nociceptive flexor response in mice. The peripheral morphine analgesia in mice which developed central analgesic tolerance to chronic morphine (10 mg/kg s.c., 5 days), was equivalent to that in vehicle-treated mice ...
H, Ueda, M, Inoue
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Influence of antineoplastic drugs on morphine analgesia and on morphine tolerance
European Journal of Pharmacology, 1999The possible influence of cisplatin, methotrexate, adriamycin and vincristine on thermal pain threshold, morphine analgesia and development of morphine tolerance was investigated in mice. In the hot-plate test, the nociceptive threshold was not affected by acute or repeated administration of any of the antineoplastic drugs used.
GENEDANI, Susanna +2 more
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Morphine as a cue in associative tolerance to morphine's analgesic effects
Pharmacology Biochemistry and Behavior, 1993This study examined the extent to which low doses of morphine paired explicitly with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test.
A, Cepeda-Benito, S T, Tiffany
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Tolerance develops to spinal morphine analgesia but not morphine-induced convulsions
European Journal of Pharmacology, 1990Administration of morphine into the spinal intrathecal (i.t.) space produced dose-dependent analgesia in the mouse. At higher doses i.t. morphine induced seizures of the hindlimbs. Mice treated chronically with morphine (75 mg pellet, s.c.) for 72 h were tolerant to the analgesic effects of i.t. morphine, but not to the proconvulsant action.
B C, Yoburn +3 more
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Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections
Brain Research, 2004Morphine analgesic potency following systemic administration was assessed in male and female mice undergoing prior and repeated intrathecal morphine injections. Although morphine ED50 values were significantly increased in both sexes relative to their respective saline-injected controls, the magnitude of tolerance was greater in females.
Eileen, Hopkins +2 more
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Stress-induced potentiation of morphine-induced analgesia in morphine-tolerant rats
Neuropharmacology, 1989This study was designed to evaluate whether or not rats that were tolerant to the analgesic action of morphine were also tolerant to stress-induced potentiation of morphine-induced analgesia. Rats were trained to drink either solutions of morphine (0.5 mg/ml) or drug-free tap water on a limited access schedule (10 min every 6 hr).
S W, Fleetwood, S G, Holtzman
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Decreased spinal morphine/clonidine antinociceptive synergism in morphine-tolerant mice
Life Sciences, 1994The antinociceptive interactions between spinally administered opioids and the alpha 2 agonist clonidine were examined in placebo and morphine pellet-implanted mice using the tail flick test. In placebo pellet-implanted animals, coadministered morphine and clonidine produced a synergistic antinociceptive effect. In mice implanted with morphine pellets,
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