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Tolerance to morphine analgesia
Pain Forum, 1999There is a growing body of evidence that implicates the role of excitatory amino acids (EEAs), in particular the N-methyl-D-aspartate (NMDA) receptor, in the development of opioid tolerance. In their Focus article, Fundytus and Coderre have proposed a model of opioid tolerance that highlights the importance of metabotropic glutamate receptors (MGIuRs ...
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Tolerance develops to spinal morphine analgesia but not morphine-induced convulsions
European Journal of Pharmacology, 1990Administration of morphine into the spinal intrathecal (i.t.) space produced dose-dependent analgesia in the mouse. At higher doses i.t. morphine induced seizures of the hindlimbs. Mice treated chronically with morphine (75 mg pellet, s.c.) for 72 h were tolerant to the analgesic effects of i.t. morphine, but not to the proconvulsant action.
B C, Yoburn +3 more
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Tolerance to morphine stimulus control: role of morphine maintenance dose
Psychopharmacology, 1990Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery.
A M, Young +5 more
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Enhancement of Morphine Antinociception by Ibogaine and Noribogaine in Morphine-Tolerant Mice
Pharmacology, 1998The effects of ibogaine, an alkaloid isolated form the bark of the African shrub, <i>Tabernathe iboga</i>, and noribogaine, a metabolite of ibogaine, on morphine antinociception were determined in male Swiss-Webster mice. Mice were rendered tolerant to morphine by implanting them with a pellet containing 25 mg of morphine base for 3 days ...
S, Sunder Sharma, H N, Bhargava
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Role of Endothelin in Neonatal Morphine Tolerance
Journal of Cardiovascular Pharmacology, 2004Management of neonatal opioid tolerance and withdrawal symptoms remains a major challenge in neonatal intensive care units. We provide evidence that central endothelin (ET) mechanisms are involved in the development of morphine tolerance in neonatal rats.
Bhagya L, Puppala +3 more
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Pharmacological Cues, Morphine Tolerance, and Morphine Withdrawal
2003Results of many studies have demonstrated an important contribution of Pavlovian conditioning to the phenomena of drug tolerance and withdrawal. Based on the conditioning analysis, cues paired with the drug administration conditionally elicit compensatory responses in anticipation of the subsequent drug-induced physiological disturbance.
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Cross-Tolerance between Ethanol and Morphine
1980Adult male Wistar rats were fed chronically a liquid diet providing 35% of the calories as ethanol (10-12 g/kg ethanol daily), while pair-fed controls received the corresponding diet with alcohol replaced by an equicaloric concentration of sucrose. Rectal temperatures, after test doses of ethanol or morphine, were measured in several groups of rats at ...
A D, Lê +3 more
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Morphine as an Inhibitor of Brain Cholinesterases in Morphine‐Tolerant and Non‐Tolerant Rats
Acta Pharmacologica et Toxicologica, 1962openaire +2 more sources