Results 201 to 210 of about 52,092 (254)

Binding of Morphine in Tolerant Rats

British Journal of Addiction to Alcohol & Other Drugs, 1968
SummaryThe proportion of bound morphine: [100 (total‐free morphine): (total morphine)] in the liver and of free morphine in the blood of tolerant rats receiving a lethal dose of morphine by intravenous infusion at 1, 3, 8 and 16 days after withdrawal were studied. The results were compared with those obtained in two groups of non‐tolerant controls. One
A, Penna-Herreros, L, Tampier, E, Sanchez   +2 more
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GABA in morphine analgesia and tolerance

Life Sciences, 1985
Drugs affecting various steps of GABA transmission exhibit analgesia in a variety of experimental models in animals; this analgesic response generally requires high doses of the drugs and does not appear to be opiate-like since the GABAergic analgesia is naloxone-insensitive and lacks dependence liability.
S P, Sivam, I K, Ho
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Tolerance to Drugs, especially to Morphine

Nature, 1960
VARIOUS theories have been put forward to elucidate the development of tolerance to a drug. For example, it has been observed by Zauder1 that “as tolerance develops (in the rat), the amount of morphine appearing in the urine decreases”. This was in accordance with Gross and Thomson's observations on the dog2. Cochin et al.
G, NADEAU, G, SOBOLEWSKI
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THIP analgesia: Cross tolerance with morphine

Life Sciences, 1983
THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridone-3-ol), a direct acting GABA receptor agonist, has been shown to have antinociceptive properties. To determine whether tolerance develops to the analgesic response, mice received multiple injections of THIP for up to 21 days after which analgesia was tested using both tail immersion and hot-plate ...
T, Andree, D A, Kendall, S J, Enna
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Haloperidol-induced tolerance to morphine catalepsy

Life Sciences, 1977
Abstract Morphine (0, 10, 17, 30 mg/kg i.p.) was administered acutely and its cataleptic action tested. Chronic haloperidol 5 mg/kg/day i.p. was then administered to these animals for 14 days. On the 16th day, the animals were retested with morphine. Chronic haloperidol induced tolerance to morphine's cataleptogenic effects.
C, Ezrin-Waters, P, Seeman
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Formation of Morphine Tolerance in Offspring of Morphine-Tolerant Animals: Neurochemical and Neuroimmune Correlates

Bulletin of Experimental Biology and Medicine, 2001
We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in ...
S V, Litvinova, V V, Aristova, V V, Shul'govskii, L A, Basharova, N N, Terebilina, L F, Panchenko   +5 more
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Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats

Peptides, 2003
Several neurotransmitter mechanisms have been proposed to play a role in the development of morphine tolerance. The present study provides evidence for the first time that endothelin (ET) antagonists can restore morphine analgesia in morphine tolerant rats.
Shaifali, Bhalla, George, Matwyshyn, Anil, Gulati   +2 more
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Tolerance to morphine stimulus control: role of morphine maintenance dose

Psychopharmacology, 1990
Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery.
A M, Young, C A, Sannerud, E S, Steigerwald, M D, Doty, W J, Lipinski, L E, Tetrick   +5 more
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Tolerance to morphine analgesia

Pain Forum, 1999
There is a growing body of evidence that implicates the role of excitatory amino acids (EEAs), in particular the N-methyl-D-aspartate (NMDA) receptor, in the development of opioid tolerance. In their Focus article, Fundytus and Coderre have proposed a model of opioid tolerance that highlights the importance of metabotropic glutamate receptors (MGIuRs ...
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Cross-tolerance to cannabinoids in morphine-tolerant rhesus monkeys

Psychopharmacology, 2015
Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects limit their use. Therapeutic utility might be improved by combining opioids with other drugs to enhance analgesic effects, but only if adverse effects are not similarly changed.Cannabinoids have been shown to enhance the antinociceptive potency of opioids ...
L R, Gerak, C, Zanettini, W, Koek, C P, France   +3 more
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