Results 131 to 140 of about 685,770 (240)

Impact of individualized opioid protocols on post‐cesarean discharge prescriptions

Pregnancy, Volume 2, Issue 6, November 2026.
Abstract Introduction Consensus on optimal prescribing of opioids at discharge following cesarean delivery remains limited. Since inpatient opioid use is a strong predictor of outpatient need, individualized approaches may improve prescribing accuracy.
Sarah W. Freeman, Mohak Mhatre, Megan J. Li, Meghan E. Beard, Leanne Ludwick, Devika Lekshmi, Sebastian Z. Ramos   +6 more
wiley   +1 more source

The OPIAID Zone Tool (Version 0.5) as a Composite Outcome for Postoperative Pain Management Quality

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 10, November 2026.
ABSTRACT Background Managing postoperative pain while minimising opioid‐related adverse drug events (ORADEs) remains a clinical challenge. The OPIAID Zone Tool is a visual scoring system designed to evaluate pain and ORADEs together. It has pain on the x‐axis and ORADEs on the y‐axis and categorises patients into zones of increased combined symptom ...
Anders Peder Højer Karlsen, Trang Xuan Minh Tran, Christian S. Meyhoff, Troels Haxholdt Lunn, Ole Mathiesen, Markus Harboe Olsen   +5 more
wiley   +1 more source

Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice. [PDF]

J Tradit Chin Med, 2023
Shuai H, Hua M, Tingting J, Rubing Y, Ziyi W, Jie Z, Jianwen S, Yongxin L.   +7 more
europepmc   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Morphine-Induced Analgesic Tolerance Effect on Gene Expression of the NMDA Receptor Subunit 1 in Rat Striatum and Prefrontal Cortex

Basic and Clinical Neuroscience, 2016
Introduction: Morphine is a potent analgesic but its continual use results in analgesic tolerance. Mechanisms of this tolerance remain to be clarified.
Shamseddin Ahmadi, Fatemeh Rafieenia, Jalal Rostamzadeh   +2 more
doaj  

Nurses' Experiences of Pain Management for Patients With Diagnosed Mental Health Conditions: A Systematic Review

Journal of Advanced Nursing, Volume 82, Issue 11, Page 9481-9506, November 2026.
ABSTRACT Aim To synthesise the available evidence related to nurses' pain assessment and management practices for patients with diagnosed mental health conditions. Design Mixed‐methods systematic review. Data Sources Medline, CINAHL, PsycINFO, SPORTDiscus and Psychology and Behavioural Sciences Collection.
Aaron Lapuz Alejandro, Yvonne Middlewick, Seng Giap Marcus Ang, Rosemary Saunders, Irene Ngune   +4 more
wiley   +1 more source

Effect of Duloxetine on the Perioperative Anxiety Status and Stress Response Following Total Hip Arthroplasty: A Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 11, Page 2417-2427, November 2026.
The perioperative administration of duloxetine alleviated anxiety, reduced the stress response and postoperative walking pain, and improved the quality of functional recovery and satisfaction in patients undergoing THA. ABSTRACT Objective The impact of psychological factors on surgical stress response has garnered extensive attention.
Bohua Li, Manxue Zhang, Qianhao Li, Lijun Cai, Liyile Chen, Xiaobing Pu, Pengde Kang   +6 more
wiley   +1 more source

Development and Validation of a Clinical Prediction Rule to Identify Preoperatively Patients With Acute Refractory Pain After Lumbar Spine Surgery

Pain Practice, Volume 26, Issue 8, November 2026.
ABSTRACT Background Preoperative risk stratification to identify patients who develop acute refractory pain after lumbar spine surgery is a first step to prevent unfavorable outcomes. In this study, we aimed to develop and internally validate a clinically relevant, multidimensional prediction rule for preoperative risk assessment.
Ilse H. van de Wijgert, Kris C. P. Vissers, Martijn W. Heymans, Akkie Rood, Moniek de Goeij, Regina L. M. van Boekel, Miranda L. van Hooff   +6 more
wiley   +1 more source

Zonisamide attenuates morphine tolerance in association with reduced spinal TLR4/p38 MAPK signaling. [PDF]

Front Pharmacol
Gei LB, Liu YH, Guo H, Zhao X, Li LL, Zhang R, Cheng HX, Feng JJ, Zeng WA, Yan Y, E RQ, Chen DT.   +11 more
europepmc   +1 more source

The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray. [PDF]

J Neuroinflammation, 2022
Ouyang H, Zhang J, Chi D, Zhang K, Huang Y, Huang J, Huang W, Bai X.   +7 more
europepmc   +1 more source