Results 111 to 120 of about 685,770 (240)

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Upregulation of μ-Opioid Receptor in the Rat Spinal Cord Contributes to the α2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain

Journal of Pain Research, 2020
Pinyi Zhang,1 Jianlong Bu,2 Xiaohong Wu,1 Lin Deng,1 Meng Chi,1 Chao Ma,3 Xiaoding Shi,1 Guonian Wang3 1Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Thoracic Surgery ...
Zhang P, Bu J, Wu X, Deng L, Chi M, Ma C, Shi X, Wang G   +7 more
doaj  

Reversal of clonidine effect on acetylcholine release during morphine tolerance.

, 1987
Effect of clonidine on acetylcholine release during morphine ...
BIANCHI, Clementina, SIMONATO, Michele, RANDO S., TANGANELLI, Sergio, BEANI, Lorenzo, ANTONELLI, Tiziana   +5 more
core  

Periaqueductal Gray Glia Modulate Morphine Tolerance Development via Soluble Tumor Necrosis Factor Signaling

, 2015
Each year, over 50 million Americans suffer from persistent pain, including debilitating headaches, joint pain, and severe back pain. Although morphine is amongst the most effective analgesics available for the management of severe pain, prolonged ...
Eidson, Lori
core   +1 more source

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

Analytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia, Sadia Tamanna Tamim, Faruq Mohammed Tashriq, Nasir Uddin, Fatematus Zhohara Alam Hima, Ulfat Sobha Surat, Mily Khastagir, Muhammad Abdul Jalil, Md. Hossain Rasel, Arman Ullah Rafi, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Prevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat

, 1996
1. The effect of ondansetron, a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, was studied in morphine-addicted rats. Morphine-dependence and tolerance, induced by drinking increasing concentrations of morphine sulphate in 5% sucrose ...
Elenita L. Sevilla, Hui, SC, Ogle, CW, Siu‐Chun G. Hui, Clive W. Ogle, Sevilla, EL   +5 more
core   +1 more source

Patient Experiences of Chronic Low Back Pain: Development of a Conceptual Model Based on a Targeted Literature Review and Qualitative Patient Interviews

Musculoskeletal Care, Volume 24, Issue 4, December 2026.
ABSTRACT Purpose Chronic low back pain (CLBP) is a persistent, debilitating condition. The United States (US) Food and Drug Administration Patient‐Focused Drug Development Guidance recommends using patient‐reported outcome (PRO) measures to assess pain and function in clinical trials and document content validity of the measures based on patient ...
Ekin Seçinti, Brittany Klooster, Rebecca Robinson, Madison C. Bernstein, Madeline Tallarico, Kaitlin Chatterton, Adriana Voci, Daniella Olonilua, Samantha R. Linton, Leighann Litcher‐Kelly, Marcia M. Mellado Lagarde, Linda A. Wietecha, John Markman   +12 more
wiley   +1 more source

Surgical removal of a perirectal melanoma through sphincterotomy and rectal wall resection in a horse

Equine Veterinary Education, Volume 38, Issue 12, Page e926-e931, December 2026.
Summary Melanomas are among the most frequent neoplasms in grey horses. Deep perirectal melanomas, however, are uncommon and challenging to excise due to their proximity to the peritoneal reflection. This report describes the successful standing removal of a large (16 × 8 × 6 cm) perirectal melanoma firmly adherent to the dorsal rectal wall in a 19 ...
R. Becker, C. Koch, M. de Preux
wiley   +1 more source

STUDIES ON TOLERANCE DEVELOPMENT TO SINGLE DOSES OF MORPHINE IN MICE

, 1976
Single-dose tolerance to the antinociceptive effect of morphine can be demonstrated using an adequate initial priming dose of morphine and allowing an interval of 48-72 h for its development.
HUIDOBRO, F, HUIDOBROTORO, JP, WAY, EL
core  

Temporal Dilution: Chemotherapy, Capitalism, and the Making of Cancer Time in Colombia

The Journal of Latin American and Caribbean Anthropology, Volume 31, Issue 4, December 2026.
ABSTRACT Through the ethnographic case of a man undergoing chemotherapy for prostate cancer at a hospital in Colombia, this article examines how chemotherapy schedules make toxicity clinically manageable while imposing rhythms that many patients cannot sustain. It develops an analytic framework centered on three interrelated temporal dynamics: temporal
Camilo Sanz
wiley   +1 more source