Results 211 to 220 of about 51,793 (252)
Some of the next articles are maybe not open access.
Influence of antineoplastic drugs on morphine analgesia and on morphine tolerance
European Journal of Pharmacology, 1999The possible influence of cisplatin, methotrexate, adriamycin and vincristine on thermal pain threshold, morphine analgesia and development of morphine tolerance was investigated in mice. In the hot-plate test, the nociceptive threshold was not affected by acute or repeated administration of any of the antineoplastic drugs used.
GENEDANI, Susanna +2 more
openaire +3 more sources
Morphine as a cue in associative tolerance to morphine's analgesic effects
Pharmacology Biochemistry and Behavior, 1993This study examined the extent to which low doses of morphine paired explicitly with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test.
A, Cepeda-Benito, S T, Tiffany
openaire +2 more sources
Tolerance develops to spinal morphine analgesia but not morphine-induced convulsions
European Journal of Pharmacology, 1990Administration of morphine into the spinal intrathecal (i.t.) space produced dose-dependent analgesia in the mouse. At higher doses i.t. morphine induced seizures of the hindlimbs. Mice treated chronically with morphine (75 mg pellet, s.c.) for 72 h were tolerant to the analgesic effects of i.t. morphine, but not to the proconvulsant action.
B C, Yoburn +3 more
openaire +2 more sources
Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance
European Journal of Pharmacology, 1988The influence of calcium channel blockers on morphine-induced analgesia and on tolerance to the chronic administration of the opiate was investigated in mice. The effects of a test dose of morphine were significantly increased by the administration of diltiazem, flunarizine, nicardipine and verapamil.
E, Contreras, L, Tamayo, M, Amigo
openaire +2 more sources
Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections
Brain Research, 2004Morphine analgesic potency following systemic administration was assessed in male and female mice undergoing prior and repeated intrathecal morphine injections. Although morphine ED50 values were significantly increased in both sexes relative to their respective saline-injected controls, the magnitude of tolerance was greater in females.
Eileen, Hopkins +2 more
openaire +2 more sources
Stress-induced potentiation of morphine-induced analgesia in morphine-tolerant rats
Neuropharmacology, 1989This study was designed to evaluate whether or not rats that were tolerant to the analgesic action of morphine were also tolerant to stress-induced potentiation of morphine-induced analgesia. Rats were trained to drink either solutions of morphine (0.5 mg/ml) or drug-free tap water on a limited access schedule (10 min every 6 hr).
S W, Fleetwood, S G, Holtzman
openaire +2 more sources
Decreased spinal morphine/clonidine antinociceptive synergism in morphine-tolerant mice
Life Sciences, 1994The antinociceptive interactions between spinally administered opioids and the alpha 2 agonist clonidine were examined in placebo and morphine pellet-implanted mice using the tail flick test. In placebo pellet-implanted animals, coadministered morphine and clonidine produced a synergistic antinociceptive effect. In mice implanted with morphine pellets,
openaire +2 more sources
Pharmacological Cues, Morphine Tolerance, and Morphine Withdrawal
2003Results of many studies have demonstrated an important contribution of Pavlovian conditioning to the phenomena of drug tolerance and withdrawal. Based on the conditioning analysis, cues paired with the drug administration conditionally elicit compensatory responses in anticipation of the subsequent drug-induced physiological disturbance.
openaire +1 more source
Molecular recognition of morphine and fentanyl by the human μ-opioid receptor
Cell, 2022Huaqiang Xu
exaly