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Dose-dependent naloxone-induced morphine withdrawal symptoms in opioid-dependent males-a double-blinded, randomized study. [PDF]
Br J Clin Pharmacol, 2020 Weisshaar S +11 more
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Lowering the Threshold. Models of Accessible Methadone and Buprenorphine Treatment [PDF]
, 2010 Keeney, Elizabeth, Saucier, Roxanne
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Intra-Administration Associations and Withdrawal Symptoms: Morphine-Elicited Morphine Withdrawal.
Experimental and Clinical Psychopharmacology, 2004On the basis of a conditioning analysis, some drug "withdrawal symptoms" are conditional responses elicited by stimuli paired with the drug effect. Prior demonstrations of conditional elicitation of withdrawal symptoms evaluated the role of environmental cues; however, pharmacological cues also typically signal a drug effect. Within each administration,
Robert V, McDonald, Shepard, Siegel
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Morphine Withdrawal Dramatically Reduces Lymphocytes in Morphine-Dependent Macaques
Journal of Neuroimmune Pharmacology, 2006The immune effects of chronic opiate exposure and/or opiate withdrawal are not well understood. The results of human studies with opiate abusers are variable and may not be able to control for important factors such as subjects' drug histories, health and nutritional status. Nonhuman primate models are necessary to control these important factors.
Michael R, Weed +4 more
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Ultrasounds during morphine withdrawal in rats
Psychopharmacology, 1991Ultrasounds (US) in rats may communicate affective states, as they occur only in highly significant situations such as maternal care, sex and aggression. Withdrawal from morphine is a manipulation which dramatically alters autonomic, somatic and motor functions; the present experiment demonstrated the production of US in this context and the influence ...
J A, Vivian, K A, Miczek
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Orphanin FQ/nociceptin inhibits morphine withdrawal
Life Sciences, 2000The influence of orphanin FQ/nociceptin (OFQ/N) on the morphine-withdrawal symptom was investigated. Withdrawal syndrome was induced in the morphine-dependent rats by an intraperitoneal (i.p.) injection of 2 mg/kg naloxone hydrochloride--an opioid receptors antagonist. Wet-dog shakes were used as a measure of the abstinence syndrome.
J, Kotlińska +4 more
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Morphine-withdrawal aggression: Sensitization by amphetamines
Psychopharmacologia, 1971Aggressive behaviors during the withdrawal from morphine sulfate (400 mg/kg/day), were potentiated by methylphenidate or d and l isomers of amphetamine. d-Amphetamine was most active, while hydroxyamphetamine was without any effect. Optimum effect of the drugs depended upon the drug dose and the time of morphine withdrawal.
H, Lal, J, O'Brien, S K, Puri
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Neurotransmitter Mechanisms of Morphine Withdrawal Syndrome
Bulletin of Experimental Biology and Medicine, 2009Activity of the major neurotransmitter systems in the brainstem and cerebellum was studied in rats with morphine withdrawal syndrome. The most significant changes were found in the brainstem of animals by the 36th hour and 7 days after morphine withdrawal.
S V, Lelevich +2 more
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PSYCHOSIS DURING WITHDRAWAL OF MORPHINE
Archives of Neurology And Psychiatry, 1947THE PSYCHOSES usually attributed to the use of morphine may be classified as follows: (1) chronic psychosis due to habitual use; (2) psychosis due to withdrawal; (3) psychosis due to idiosyncrasy to the drug. At the United States Public Health Service Hospital, Lexington, Ky., which is devoted primarily to the treatment of drug addiction, and where ...
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