Results 91 to 100 of about 567,251 (277)
On a model mechanism for the spatial patterning of teeth primordia in the Alligator [PDF]
, 1996 We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role ...
Cruywagen, G. C. +6 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang +12 more
wiley +1 more source
Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells
Nature CommunicationsArterial blood transport into peripheral organs is indispensable for developmental growth, homeostasis and tissue repair. While it is appreciated that defective formation or compromised function of arteries is associated with a range of human diseases ...
Esther Bovay +8 more
doaj +1 more source
Simplifying Genotyping of Mutants from Genome Editing with a Parallel qPCR-Based iGenotype Index
CellsTargeted genome editing is a powerful tool in reverse genetic studies of gene function in many aspects of biological and pathological processes. The CRISPR/Cas system or engineered endonucleases such as ZFNs and TALENs are the most widely used genome ...
Liezhen Fu +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source
Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes
Molecular Systems Biology, 2018 Over the past few years, tools that make use of the Cas9 nuclease have led to many breakthroughs, including in the control of gene expression. The catalytically dead variant of Cas9 known as dCas9 can be guided by small RNAs to block transcription of ...
Antoine Vigouroux +4 more
doaj +1 more source
eLife, 2020 Blood vessels are integrated into different organ environments with distinct properties and physiology (Augustin and Koh, 2017). A striking example of organ-specific specialization is the bone vasculature where certain molecular signals yield the ...
Kishor K Sivaraj +8 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This work pioneers melt electrowriting (MEW) of polyethylene vinyl acetate (PEVA) to fabricate ultra‐compliant, high‐resolution scaffolds. By integrating microscale precision with soft tissue‐like biomechanics, PEVA overcomes stiffness‐driven limitations of conventional MEW polymers, establishing a mechanically biomimetic platform for soft tissue ...
Finn Snow +9 more
wiley +1 more source
Endothelial EphB4 maintains vascular integrity and transport function in adult heart
eLife, 2019 The homeostasis of heart and other organs relies on the appropriate provision of nutrients and functional specialization of the local vasculature. Here, we have used mouse genetics, imaging and cell biology approaches to investigate how homeostasis in ...
Guillermo Luxán +16 more
doaj +1 more source
Analysis of Gram-negative Bacteria Peptidoglycan by Ultra-performance Liquid Chromatography
Bio-Protocol, 2020 Bacteria are surrounded by a protective peptidoglycan cell wall. Provided that this structure and the enzymes involved are the preferred target for our most successful antibiotics, determining its structural and chemical complexity is of the highest ...
Laura Alvarez +3 more
doaj +1 more source