Results 51 to 60 of about 673,537 (375)

FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation

Nature Communications, 2023
Exocrine acinar cells in salivary glands (SG) are critical for oral health and loss of functional acinar cells is a major clinical challenge. Fibroblast growth factor receptors (FGFR) are essential for early development of multiple organs, including SG ...
Marit H. Aure, Jennifer M. Symonds, Carlos U. Villapudua, Joshua T. Dodge, Sabine Werner, Wendy M. Knosp, Matthew P. Hoffman   +6 more
doaj   +1 more source

Thyroid hormone receptor beta is critical for intestinal remodeling during Xenopus tropicalis metamorphosis

Cell & Bioscience, 2020
Background Thyroid hormone (T3) is critical for development in all vertebrates. The mechanism underlying T3 effect has been difficult to study due to the uterus-enclosed nature of mammalian embryos.
Yuki Shibata, Yuta Tanizaki, Yun-Bo Shi
doaj   +1 more source

The Kinetic Basis of Morphogenesis

, 2015
It has been shown recently (Shalygo, 2014) that stationary and dynamic patterns can arise in the proposed one-component model of the analog (continuous state) kinetic automaton, or kinon for short, defined as a reflexive dynamical system with active ...
Shalygo, Yuri
core   +1 more source

Polarized cortical tension drives zebrafish epiboly movements [PDF]

, 2016
The principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly is an essential embryonic event in which three tissues coordinate to direct the expansion of the blastoderm.
Amayra Hernández‐Vega, Concha ML, Daniel Navajas, Enrique Martín‐Blanco, Ignacio Pagonabarraga, Julien Colombelli, María Marsal, Philippe‐Alexandre Pouille, Solnica‐Krezel L, Sébastien Tosi, Tomás Luque, Warga RM, Weliky M, Westerfield M   +13 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Longitudinal growth of the Saccharina kelp embryo depends on actin filaments that control the formation of a corset-like structure composed of alginate

Scientific Reports
The initiation of embryogenesis in the kelp Saccharina latissima is accompanied by significant anisotropy in cell shape. Using monoclonal antibodies, we show that this anisotropy coincides with a spatio-temporal pattern of accumulation of alginates in ...
Samuel Boscq, Ioannis Theodorou, Roman Milstein, Aude Le Bail, Sabine Chenivesse, Bernard Billoud, Bénédicte Charrier   +6 more
doaj   +1 more source

GFP-Tagged Protein Detection by Electron Microscopy Using a GBP-APEX Tool in Drosophila

Frontiers in Cell and Developmental Biology, 2021
In cell biology, detection of protein subcellular localizations is often achieved by optical microscopy techniques and more rarely by electron microscopy (EM) despite the greater resolution offered by EM.
Fred Bernard, Julie Jouette, Catherine Durieu, Rémi Le Borgne, Antoine Guichet, Sandra Claret   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Branch Mode Selection during Early Lung Development [PDF]

, 2012
Many organs of higher organisms, such as the vascular system, lung, kidney, pancreas, liver and glands, are heavily branched structures. The branching process during lung development has been studied in great detail and is remarkably stereotyped.
A Kicheva, A Weddemann, A White, AA Mailleux, AC White, AD Bragg, AJ Bard, B Hebert, B West, B Xu, BA Hyatt, BA Hyatt, C Chiang, C Nelson, Conradin Kraemer, CV Pepicelli, D Hartmann, D Hartmann, D Lebeche, D Warburton, Dagmar Iber, Denis Menshykau, E Crampin, E Domyan, E Weibel, Edmund J. Crampin, G Carraro, H Kitaoka, H Kitaoka, H Min, IJ Cutress, IV Nesmelova, J Maina, J Motoyama, J Murray, J Ries, J Sharpe, JA Goetz, JC Clark, K Sekine, KA Moore, KM Short, LAD Miller, LL Abler, LV Goodrich, M Affolter, M Carin, M Kumar, M Unbekandt, M Weaver, M Weaver, MC Eblaghie, MC Eblaghie, N Gjorevski, N Kim, P Chuang, P Nyeng, PM Lewis, R Aris, R Vuilleumier, RJ Metzger, RJ Metzger, RS Moura, RW Glenny, S Bellusci, S Bellusci, S Bellusci, S Bellusci, S Kondo, S Lubkin, S Lubkin, S Malpel, SK Ramasamy, SR Yu, T Bollenbach, T Hirashima, T Miura, T Miura, T Nelson, T Okubo, T Wilson, TM Moore, TR Nelson, U Frey, V Thummler, W Cardoso, WV Cardoso, X Wan, Y Litingtung   +88 more
core   +6 more sources

Astrocytic Neuroligins Control Astrocyte Morphogenesis and Synaptogenesis

Nature, 2017
Astrocytes are complex glial cells with numerous fine cellular processes that infiltrate the neuropil and interact with synapses. The mechanisms that control the establishment of astrocyte morphology are unknown, and it is unclear whether impairing ...
Jeffery A Stogsdill, J. Ramírez, Di Liu, Yong-Ho Kim, Katherine T. Baldwin, Eray Enustun, Tiffany Ejikeme, R. Ji, C. Eroglu   +8 more
semanticscholar   +1 more source