Results 61 to 70 of about 459,719 (297)

Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages

Disease Models & Mechanisms, 2019
Laterality defects are developmental disorders resulting from aberrant left/right patterning. In the most severe cases, such as in heterotaxy, they are associated with complex malformations of the heart.
Audrey Desgrange, Johanna Lokmer, Carmen Marchiol, Lucile Houyel, Sigolène M. Meilhac   +4 more
doaj   +1 more source

Direct activation of tRNA methyltransferase-like 1 (Mettl1) gene by thyroid hormone receptor implicates a role in adult intestinal stem cell development and proliferation during Xenopus tropicalis metamorphosis

Cell & Bioscience, 2020
Background Thyroid hormone (T3) plays an important role in vertebrate development. Compared to the postembryonic development of uterus-enclosed mammalian embryos, T3-dependent amphibian metamorphosis is advantageous for studying the function of T3 and T3
Wonho Na, Liezhen Fu, Nga Luu, Yun-Bo Shi   +3 more
doaj   +1 more source

Theory of Morphogenesis [PDF]

Journal of Computational Biology, 2018
A model of morphogenesis is proposed based on seven explicit postulates. The mathematical import and biological significance of the postulates are explored and discussed.
Minarsky, A, Morozova, N, Penner, R, Soulé, C   +3 more
openaire   +5 more sources

Mechanical control of morphogenesis at the shoot apex [PDF]

, 2013
Morphogenesis does not just require the correct expression of patterning genes; these genes must induce the precise mechanical changes necessary to produce a new form.
Landrein, Benoit, Nakayama, Naomi, Louveaux, Marion, Neumann, Enrique D., Peaucelle, Alexis, Couturier, Etienne, Weber, Alain, Robinson, Sarah, Neumann, Enrique, Burian, Agata, Couturier E, Robinson S, Weber A, Landrein B, Peaucelle A, Louveaux M, Neumann ED, Burian A, Nakayama N   +18 more
core   +3 more sources

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Pericytes are organ-specific regulators of tissue morphogenesis

Nature Communications
Endothelial cells lining the vessel network are indispensable for vascular transport but also provide paracrine signals controlling the behavior of nearby cell types. Pericytes are another essential component of the vessel wall, but little is known about
Seyed Javad Rasouli, Kai Kruse, Rodrigo Diéguez-Hurtado, Parisa Ghanbari, Anusha Aravamudhan, Mara E. Pitulescu, Ralf H. Adams   +6 more
doaj   +1 more source

Studies on the Morphogenesis of Murine Cytomegalovirus [PDF]

, 1986
Two modes of assembly of murine cytomegalovirus (MCMV) were observed in cultured mouse embryo fïbroblasts, generating two morphologically different types of viral particles: monocapsid virions and multicapsid virions.
Reddehase, M. J., Reddehase, Matthias J., U.H. Koszinowski, G.M. Keil, M.J. Reddehase, Koszinowski, Ulrich H., Koszinowski, U. H., Keil, Günther M., F. Weiland, Weiland, Frank   +9 more
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Deep learning-based detection of murine congenital heart defects from µCT scans

Communications Biology
Micro-computed tomography (μCT) provides 3D images of congenital heart defects (CHD) in mice. However, diagnosing CHD from μCT scans is time-consuming and requires clinical expertise. Here, we present a deep learning approach to automatically segment and
Hoa Nguyen, Audrey Desgrange, Amaia Ochandorena-Saa, Vanessa Benhamo, Ségolène Bernheim, Lucile Houyel, Sigolène M. Meilhac, Christophe Zimmer   +7 more
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source