Results 51 to 60 of about 378,865 (268)

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Pericytes are organ-specific regulators of tissue morphogenesis

Nature Communications
Endothelial cells lining the vessel network are indispensable for vascular transport but also provide paracrine signals controlling the behavior of nearby cell types. Pericytes are another essential component of the vessel wall, but little is known about
Seyed Javad Rasouli, Kai Kruse, Rodrigo Diéguez-Hurtado, Parisa Ghanbari, Anusha Aravamudhan, Mara E. Pitulescu, Ralf H. Adams   +6 more
doaj   +1 more source

Nanofiber‐Supported Decellularized Matrix Membrane Creates a Biomimetic Biochemical and Biophysical Niche for Intestinal Organoid Epithelium

Advanced Healthcare Materials, EarlyView.
A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn, Hyeonji Kim, Nam Than, Juhyeok Kim, Jangwon Yoon, Dohui Kim, Hyun Jung Kim, Dong Sung Kim   +7 more
wiley   +1 more source

Foliar biostimulant from Kappaphycus alvarezii enhances growth and development of peppermint plants (Mentha × piperita)

Discover Plants
This study aimed to evaluate the morphophysiological and biochemical effects of foliar application of Kappaphycus alvarezii aqueous extracts in the development of peppermint (Mentha × piperita) plants grown in a greenhouse in Brazil.
Aline Nunes, Felipe de Souza Dutra, Eva Regina Oliveira, Camila Pimentel Martins, Alex Ricardo Schneider, Gadiel Zilto Azevedo, Lohan Rodrigues Brandão Santos, Isabella Feijão de Araujo, Milene Stefani Pereira-Vasques, Gean Charles Monteiro, Valéria Cress Gelli, Marcelo Maraschin, Giuseppina Pace Pereira Lima   +12 more
doaj   +1 more source

Bioelectricity in Morphogenesis

Annual Review of Cell and Developmental Biology
Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities influence single-cell and collective cell behaviors in processes such as embryo development, tissue repair, and even disease.
Custodio O, Nunes, Elias H, Barriga
openaire   +2 more sources

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Sox8 is essential for vertebrate gastrulation

EMBO Reports
Gastrulation is a fundamental developmental process during which germ layers are formed and the body axes are defined by the precise orchestration of cell movements and fate specification. Here, we identify the SOXE transcription factor Sox8 as a pivotal
Sofia Moreira, Artemis G Korovesi, Elias H Barriga   +2 more
doaj   +1 more source

Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages

Disease Models & Mechanisms, 2019
Laterality defects are developmental disorders resulting from aberrant left/right patterning. In the most severe cases, such as in heterotaxy, they are associated with complex malformations of the heart.
Audrey Desgrange, Johanna Lokmer, Carmen Marchiol, Lucile Houyel, Sigolène M. Meilhac   +4 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

A 3D‐Printed Vascular‐Like Perfusion Tumor‐on‐a‐Chip Recapitulates High‐Grade Breast Cancer With in Vivo‐Relevant Drug Resistance

Advanced Healthcare Materials, EarlyView.
A high‐resolution 3D‐printed tumor‐on‐a‐chip platform sustains breast cancer tissues at in vivo–like cell densities through vascular‐like perfusion. This engineered system recapitulates grade‐dependent molecular features and exhibits drug‐resistance profiles that uniquely align with clinically relevant Cmax values.
Geonhui Lee, Bingjie Sun, Nicholas X. Fang, Chunguang Xia   +3 more
wiley   +1 more source