Results 51 to 60 of about 424,553 (315)

Exposure to outdoor artificial light at night is associated with a higher risk of ulcerative colitis: a prospective cohort study from the UK Biobank

Frontiers in Public Health
BackgroundInflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, and environmental factors are believed to play an important role in its pathogenesis.
Jiamiao Chen, Jiamiao Chen, Laifu Li, Laifu Li, Yan Ran, Yan Ran, Zhuoya Sun, Zhuoya Sun, Shiwei Lu, Shiwei Lu, Yan Zhuang, Yan Zhuang, Lianli Wang, Lianli Wang, Yating Sun, Yating Sun, Fei Dai, Fei Dai   +17 more
doaj   +1 more source

Automatic diagnosis of extraocular muscle palsy based on machine learning and diplopia images [PDF]

International Journal of Ophthalmology
AIM: To develop different machine learning models to train and test diplopia images and data generated by the computerized diplopia test. METHODS: Diplopia images and data generated by computerized diplopia tests, along with patient medical records, were
Xiao-Lu Jin, Xue-Mei Li, Tie-Juan Liu, Ling-Yun Zhou   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Esophageal High Pressure Zones: Effect of Perisophageal Structures on Esophageal Manometric Recording

Canadian Journal of Gastroenterology, 1994
During the course of esophageal motility studies, short zones of elevated esophageal baseline pressure are occasionally noticed. The aim of this study is to determine their frequency and their cause. Among 77 consecutive esophageal manometries (group 1),
G Bédard, A Pellicano, R Ste-Marie
doaj   +1 more source

Boundedness and Exponential Stabilization in a Parabolic-Elliptic Keller--Segel Model with Signal-dependent Motilities for Local Sensing Chemotaxis [PDF]

, 2020
Jie Jiang
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Differences in the progression of liver disease in male and female rats induced by TAA: considerations in the development of pharmacological therapies

Annals of Hepatology
Introduction and Objectives: Thioacetamide (TAA) is a hepatotoxic agent that causes fibrosis, cirrhosis, and cancer. Various doses and regimens of TAA have been tested in different murine models to validate hepatoprotective compounds.
Jesús Dorantes-Alvarez, Moisés Martínez-Castillo, Adrián Flores-Sánchez, Ángel García-López, Luz Castro-Hernández, Abigail Hernandez-Barragan, Marisela Hernández-Santillán, Gabriela Gutierrez-Reyes   +7 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite opposite effects in heart contraction

Nature Communications
Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against these diseases are small molecules directly modulating the force produced by β-cardiac myosin ...
Daniel Auguin, Julien Robert-Paganin, Stéphane Réty, Carlos Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans-Joachim Knölker, Anne Houdusse   +8 more
doaj   +1 more source

Supplementary Figure S8 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions [PDF]

, 2023
Brooke Helfer, Bernard C. Boswell, Darren Finlay, Angel Ciprés, Kristiina Vuori, Tae‐Bong Kang, David Wallach, Andrea Dorfleutner, Jill M. Lahti, Daniel C. Flynn, Steven M. Frisch   +10 more
openalex   +1 more source