Results 51 to 60 of about 20,890 (261)

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Leveling up language learning: mobile-assisted and gamification for empowering slow learners—a literature review [PDF]

PeerJ Computer Science
Acquiring a new language remains a significant challenge, particularly for slow learners who struggle with retention, comprehension, and motivation.
Zeeshan Ahmad, Atif Alvi, Nurhizam Safie, Kashif Ishaq, Naeem A. Nawaz, Abdul Basit Dogar   +5 more
doaj   +2 more sources

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Effectiveness of a hybrid, obesity-specific counselling programme in improving medical students’ self-efficacy and motivational interviewing skills for paediatric obesity counselling

BMC Medical Education
Background There remain significant barriers to healthcare providers counselling children with obesity and their families on lifestyle modifications to improve health outcomes. Obesity-specific counselling training aims to overcome some of these barriers
Wang Chin Eileen Ng, Rachana Koura, Khairunisa Binte Khaider, Chu Shan Elaine Chew, Courtney Davis   +4 more
doaj   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

La dimensione relazionale e autoregolativa nei contesti educativi inclusivi [The relational and self-regulatory dimension in inclusive educational contexts]

Open Journal of Humanities
In the current pedagogical landscape, the integration of cognitive, emotional, and motivational dimensions emerges as the cornerstone for truly inclusive teaching.
Diletta Chiusaroli
doaj   +1 more source

The model of creation of energy-saving competence of students of high school

E3S Web of Conferences, 2016
This article considers the most important conditions for the creationof energy-saving competence of students – undergraduate training. The actualityof the problem is caused by low energy efficiency of industrial production, significantly reduces the ...
Zeer Evald, Symaniuk Elvira, Pecherkina Anna, Stepanova Anastasia, Symaniuk Nina   +4 more
doaj   +1 more source

Electrocatalytic Urea Waste Valorization via Water Electrolysis: Transition‐Metal Phosphides for Sustainable Hydrogen Production

Advanced Energy Materials, EarlyView.
This article provides a comprehensive analysis of transition metal phosphides (TMP) as electrocatalysts for urea‐assisted water electrolysis, highlighting the critical role of phosphorus engineering in modulating electronic structure, optimizing active sites, and enhancing catalytic durability.
Shivalingayya Gaddimath, Varsha Kashanner, Soumya Kulkarni, Vishal Sorathiya, Anitha Bamani, Rajveer Singh Rajaura, Mahaveer Kurkuri, Shambhulinga Aralekallu, Yogendra Kumar Mishra   +8 more
wiley   +1 more source