Identification and quantitative assessment of motor complications in Parkinson’s disease using the Parkinson’s KinetiGraph™ [PDF]
Frontiers in Aging Neuroscience, 2023 IntroductionEffective management and therapies for the motor complications of Parkinson’s disease (PD) require appropriate clinical evaluation. The Parkinson’s KinetiGraph™ (PKG) is a wearable biosensor system that can record the motion characteristics ...
Yan Qu +4 more
doaj +4 more sources
Pharmacokinetics of Levodopa and 3-O-Methyldopa in Parkinsonian Patients Treated with Levodopa and Ropinirole and in Patients with Motor Complications [PDF]
Pharmaceutics, 2021 Parkinson’s disease (PD) is a progressive, neurodegenerative disorder primarily affecting dopaminergic neuronal systems, with impaired motor function as a consequence.
Urszula Adamiak-Giera +6 more
doaj +4 more sources
Motor Complications of Dopaminergic Medications in Parkinson's Disease [PDF]
Seminars in Neurology, 2017 Motor complications are a consequence of the chronic treatment of Parkinson's disease (PD) and include motor fluctuations (wearing-off phenomenon) and levodopa-induced dyskinesia. Both can have a significant impact on functionality and quality of life; thus, proper recognition and management is essential.
Christopher Hess +2 more
exaly +5 more sources
Factors associated with motor complications in Parkinson's disease [PDF]
Brain and Behavior, 2017 AbstractObjectivesLevodopa is the most effective therapy for treating Parkinson's disease (PD); however, side effects such as dyskinesias and motor fluctuations may occur after some years of its usage. The aims of this study were to assess the frequency of and factors associated with motor complications among PD patients on levodopa treatment.MethodsIn
Pille Taba +2 more
exaly +4 more sources
Motor Complications in Parkinson's Disease [PDF]
International Journal of Neuroscience, 2011 Management of motor complications in advanced Parkinson's disease (PD) can be challenging. The main complications are inadequate dopaminergic tone ("off" time and dose failures) and excess dopaminergic tone (dyskinesia). These motor complications increase as PD progresses.
William Ondo
exaly +3 more sources
The Comparative Efficacy of Non-ergot Dopamine Agonist and Potential Risk Factors for Motor Complications and Side Effects From NEDA Use in Early Parkinson's Disease: Evidence From Clinical Trials [PDF]
Frontiers in Aging Neuroscience, 2022 Background/ObjectivesNon-ergot dopamine agonist (NEDA) are recommended as the first-line treatment for patients with early Parkinson's disease (PD) because of their efficacy in treating PD motor symptoms.
Chunxiao Wu +8 more
doaj +2 more sources
Levodopa-induced motor complications associated with benserazide and carbidopa in Parkinson’s disease: a disproportionality analysis of the FAERS database [PDF]
Frontiers in PharmacologyBackgroundLevodopa-induced motor complications are a significant concern in the treatment of Parkinson’s disease (PD). Dopamine decarboxylase inhibitors (DCIs) such as benserazide (BSZ) and carbidopa (CD) are commonly used in conjunction with levodopa to
Huaide Qiu, Cheng Liu, Zhixiang Wang
doaj +2 more sources
Effect of deep brain stimulation on motor complications in Parkinson’s disease: a systematic review and meta-analysis [PDF]
Frontiers in Human NeuroscienceBackgroundDeep brain stimulation (DBS) significantly improves tremor, rigidity, bradykinesia, and dyskinesia for patients with Parkinson’s disease (PD), but gait and speech remain inconsistent.
Hu Xu +6 more
doaj +2 more sources
Neurostimulation for Parkinson's Disease with Early Motor Complications [PDF]
New England Journal of Medicine, 2013 Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications. We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease.In this 2-year trial, we randomly assigned 251 patients with Parkinson's ...
GÜNTHER Deuschl +2 more
exaly +14 more sources
Lack of Association Between Mutations and Motor Complications in European and American Parkinson’s Disease Cohorts [PDF]
Journal of Parkinson’s Disease, 2021 Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF).
Jodi Maple-Grødem +14 more
doaj +2 more sources