Results 41 to 50 of about 173,723 (245)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
Journal of Parkinson’s Disease, 2019 Background: Dyskinesia, wearing off (WO) and freezing of gait (FOG) are troublesome complications degrading quality of life in the course of Parkinson’s disease (PD). Objective: This study evaluated the gross chronological trend of 4 motor complications -
Young Eun Kim +4 more
doaj +1 more source
GBA Variants Influence Motor and Non-Motor Features of Parkinson's Disease. [PDF]
PLoS ONE, 2016 The presence of mutations in glucocerebrosidase (GBA) gene is a known factor increasing the risk of developing Parkinson's disease (PD). Mutations carriers have earlier disease onset and are more likely to develop neuropsychiatric symptoms than other ...
Silvia Jesús +11 more
doaj +1 more source
Parkinson’s Disease Unfolding Case Study
Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2021 Young onset Parkinson’s disease (YOPD) is defined as idiopathic Parkinson’s disease (IPPD) affecting people between the ages of 21 and 40 years old; it makes up approx. 5% of all Parkinson’s Disease patients.
Brandon H. Parkyn, Colleen Marshall
doaj +1 more source
Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas +3 more
wiley +1 more source
A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho +7 more
wiley +1 more source
Electro-clinical features and management of the late stage of Lafora disease
Frontiers in Neurology, 2022 PurposeThe aim of this study was to elucidate the electro-clinical features and management of the late stage of Lafora disease (LD).MethodsWe investigated the electro-clinical data and medical complications of three LD patients with mutations in EPM2A ...
Giuseppe d'Orsi +5 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola +4 more
wiley +1 more source
Review: Improving symptom control in early Parkinson’s disease
Therapeutic Advances in Neurological Disorders, 2009 Motor symptoms in Parkinson’s disease (PD) are caused by a severe loss of pigmented dopamine-producing nigro-striatal neurons. Symptomatic therapies provide benefit for motor features by restoring dopamine receptor stimulation.
Stuart H. Isaacson, Robert A. Hauser
doaj +1 more source
l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation
Neurobiology of Disease, 2008 The emergence of levodopa (l-DOPA)-induced dyskinesia and motor fluctuations represents a major clinical problem in Parkinson's disease (PD). While it has been suggested that the daily dose of l-DOPA can play a critical role, the mechanisms linking l ...
Barbara Picconi +8 more
doaj +1 more source