Results 91 to 100 of about 925,078 (312)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
On the Nature of Fear of Falling in Parkinson’s Disease
Behavioural Neurology, 2011 In the elderly, fear of falling (FoF) can lead to activity restriction and affect quality of life (QoL). Our aim was to identify the characteristics of FoF in Parkinson's disease and assess its impact on QoL.
S. Rahman +3 more
doaj +1 more source
A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]
, 2008 Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin +3 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The Factors that Induce or Overcome Freezing of Gait in Parkinson’s Disease
Behavioural Neurology, 2008 Freezing of gait (FoG), a transient halt in walking, is a major mobility problem for patients with Parkinson’s disease (PD). This study examined the factors that induce FoG, and identified the cues and strategies that help overcome it through a postal ...
S. Rahman +3 more
doaj +1 more source
Impaired speech recognition : a thesis presented in partial fulfilment of the requirements for the degree of Master of Information Sciences in Computer Science at Massey University, Albany, New Zealand. [PDF]
, 2015 The purpose of this thesis is to present a novel mobile health application that can recognize impaired speech (using audio signals) and turn it into understandable speech.
Almujil, Mohammed Nasser
core
The Kantian Roots of Merleau-Ponty's Account of Pathology [PDF]
, 2014 One of the more striking aspects of Maurice Merleau-Ponty's Phenomenology of Perception (1945) is his use of psychological case studies in pathology.
Matherne, Samantha
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Behavioural Neurology, 2012 Changes of cognitive function in PD have been extensively documented and defined as a ‘frontal’ type executive dysfunction. One of the main components of this executive dysfunction is the impairment of verbal fluency.
Ignacio Obeso +4 more
doaj +1 more source