Results 241 to 250 of about 275,912 (292)

Non‐Motor Fluctuations in Parkinson's Disease: Validation of the Non‐Motor Fluctuation Assessment Questionnaire

Movement Disorders, 2021
ABSTRACTBackgroundIn patients with Parkinson's disease (PD), sleep, mood, cognitive, autonomic, and other non‐motor symptoms may fluctuate in a manner similar to motor symptoms.ObjectivesTo validate a final version of a patient‐rated questionnaire that captures the presence and severity of non‐motor fluctuations in levodopa‐treated PD patients (NoMoFA).
Galit Kleiner, Hubert H. Fernandez, Kelvin L. Chou, Alfonso Fasano, Kevin R. Duque, Diana Hengartner, Albie Law, Adam Margolius, Yu‐Yan Poon, Michel Sáenz Farret, Philip Saleh, Joaquin A. Vizcarra, Glenn T. Stebbins, Alberto J. Espay   +13 more
openaire   +3 more sources

Do neuropsychiatric fluctuations temporally match motor fluctuations in Parkinson’s disease?

Neurological Sciences, 2022
In Parkinson's disease (PD), non-motor fluctuations (NMFs), especially neuropsychiatric fluctuations, often coexist with motor fluctuations (MFs) but are often under-recognized by physicians and patients.To investigate the relationship between MFs and neuropsychiatric fluctuations in PD.PD patients with MFs and NMFs were enrolled.
Del Prete, Eleonora, Schmitt, Emmanuelle, Meoni, Sara, Fraix, Valerie, Castrioto, Anna, Pelissier, Pierre, Ceravolo, Roberto, Moro, Elena   +7 more
openaire   +4 more sources

Motor fluctuations in Parkinson’s disease

Journal of the Neurological Sciences, 1999
To assess patterns, prevalence, and risk factors of motor fluctuations in an unselected population of Parkinson's disease patients attending Movement Disorders Clinic of a tertiary hospital.Eighty patients with Parkinson's disease were interviewed and data about their clinical characteristics, motor fluctuations, i.e. dyskinesia, dystonia, motor blocks
A P, Denny, M, Behari
openaire   +2 more sources

Fluctuation driven ratchets: Molecular motors

Physical Review Letters, 1994
The motion of a heavily damped Brownian particle in a periodic potential subject to a dichotomously fluctuating perturbation is considered. We show that even if the net force is always zero, flow is induced by a fluctuation of the energy barrier, but only at flipping times roughly in between the adiabatic adjustment times on the left and right of the ...
, Astumian, , Bier
openaire   +2 more sources

Motor and non‐motor fluctuations

2007
Publisher Summary Treatment of Parkinson's disease (PD) is based on dopamine replacement, either in the form of the dopamine precursor, levodopa or via directly acting dopamine receptor agonists. Early treatment of PD with these agents generally results in effective and sustained control of motor symptoms which last for several years.
Susan H, Fox, Anthony E, Lang
openaire   +2 more sources

Emergence of non-motor fluctuations with reference to motor fluctuations in Parkinson's disease

Parkinsonism & Related Disorders, 2018
Non-motor fluctuations (NMF) and motor fluctuations (MF) are frequent in patients with Parkinson's disease (PD) with long-term medical treatment. We aimed to examine the timing of the emergence of NMF with reference to MF in a prospective cohort of patients with PD without symptom fluctuations.A total of 334 patients with PD who had neither MF nor NMF ...
Aryun Kim, Han-Joon Kim, Chae Won Shin, Ahro Kim, Yoon Kim, Mihee Jang, Yu Jin Jung, Woong-Woo Lee, Hyeyoung Park, Beomseok Jeon   +9 more
openaire   +2 more sources

Parkinson’s disease: Motor fluctuations

Current Treatment Options in Neurology, 1999
Motor fluctuations represent important late complications of Parkinson's disease treated with levodopa. Although treatment of these problems has improved with the emergence of numerous pharmacologic and surgical therapies, the various options can make it confusing. Pharmacologic treatment is the first step.
openaire   +2 more sources

Parkinson’s Disease and Motor Fluctuations

Current Treatment Options in Neurology, 2010
Many important advances for the treatment of Parkinson's disease (PD) have been made over the past decade, and quality of life has improved for most patients. Nonetheless, motor fluctuations in the form of wearing off with the re-emergence of parkinsonian symptoms and hyperkinetic movements (dyskinesias) often arise as a complication of long-term ...
openaire   +2 more sources

Medical Management of Motor Fluctuations

Neurologic Clinics, 2008
Given the magnitude of the problem of motor fluctuations in patients who have Parkinson's disease treated with levodopa, a significant effort has been expended by physicians, researchers, and pharmaceutical manufacturers over the years to find effective treatments.
openaire   +2 more sources

Prevention and treatment of motor fluctuations

Parkinsonism & Related Disorders, 2003
The symptoms of Parkinson's disease can become increasingly difficult to control as the disease advances, particularly with the development of motor complications, such as end-of-dose wearing-off and dyskinesias, following long-term therapy. At this stage, the patient is frequently referred to a Parkinson's disease specialist for advice on the ...
openaire   +2 more sources