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Fluctuation relations and fluctuation-response relations for molecular motors
AIP Conference Proceedings, 2011Fluctuation relations are a set of remarkable relations obeyed by a large class of systems and arbitrarily far from equilibrium. It is interesting to discuss the implications of these relations for molecular motors, which are chemically driven enzymes.
G. Verley +4 more
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Motor fluctuations in Parkinson's disease
Journal of Neurology, 2007Almost all patients with Parkinson's disease will eventually require levodopa during the course of their disease. The effectiveness of levodopa is evident, but earlier use and higher doses are causative of the emergence of motor fluctuations.
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Daily fluctuations in Honolulu motor vehicle accidents
Accident Analysis & Prevention, 1995Changes in daily motor vehicle accidents during 1990 are examined for the City and County of Honolulu. Adjusting for changed reporting criteria, daily accidents fluctuate according to an interaction between traffic volume, weekday travel patterns, holidays and weather. Fridays, particularly, and Saturdays have more daily accidents.
N, Levine, K E, Kim, L H, Nitz
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Motor Fluctuations in Levodopa Treatment: Clinical Pharmacology
European Neurology, 1996Fluctuations in motor performance and dyskinesias are a common problem in the long-term management of Parkinson's disease. The pharmacokinetics and the pharmacodynamics of levodopa, loss of presynaptic dopamine terminals, alterations in postsynaptic dopamine receptor sensitivity, or changes in the modulatory influences of nondopaminergic transmitter ...
F, Stocchi +3 more
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Revue neurologique, 2003
The therapeutic approach of motor fluctuations is based on the need for recognizing various types of motor fluctuations for each patient by a meticulous interrogation and also to have a good knowledge of the pharmacology of the various anti-parkinsonian drugs.
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The therapeutic approach of motor fluctuations is based on the need for recognizing various types of motor fluctuations for each patient by a meticulous interrogation and also to have a good knowledge of the pharmacology of the various anti-parkinsonian drugs.
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Motor Fluctuation and Levodopa Absorption
1998Levodopa is the most effective and reliable drug for Parkinson’s disease. Levodopa therapy, however, generally produces motor fluctuation such as wearing-off, on-off, or deterioration of levodopa effects. “Wearing-off” is the most frequently encountered motor fluctuation.
Miho Murata, Ichiro Kanazawa
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Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations
Neurology, 2000To test the efficacy, tolerance, and safety of low-dose oral estrogen in postmenopausal women with PD associated with motor fluctuations.Motor fluctuations in PD may be predictable or unpredictable, and eventually affect most patients after long-term levodopa therapy.
K L, Tsang, S L, Ho, S K, Lo
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Basic mechanisms of motor fluctuations.
Neurology, 1994Patients with Parkinson's disease generally have a smooth clinical response from levodopa therapy for the first 3 to 5 years. Motor fluctuations later become noticeable and may ultimately give way to unpredictable responses to treatment. Mechanisms responsible for motor fluctuations are not fully understood, but can be separated into three groups: (1 ...
J I, Sage, M H, Mark
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Management of Motor Fluctuations in Parkinson’s Disease
European Neurology, 1996A complication of chronic levodopa therapy is a shortening of benefit of each dose. Peripheral pharmacokinetics, central pharmacokinetics, and central pharmacodynamics are involved in the pathophysiology of motor fluctuations. Strategies to improve 'wearing-off' fluctuations attempt to provide more constant plasma levodopa levels or more continuous ...
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Pathophysiology of motor fluctuations in Parkinson's disease
Movement Disorders, 2005Loss of dopamine neurons in Parkinson's disease (PD) initiates a complex stream of effects that results in the development of tremor, bradykinesia, and rigidity. While levodopa remains the most effective drug for the symptomatic treatment of PD, its chronic administration is associated with the development of motor fluctuations and dyskinesias.
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