Results 1 to 10 of about 2,182,272 (358)

Motor neurons and the generation of spinal motor neurons diversity [PDF]

Frontiers in Cellular Neuroscience, 2014
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS) controlling a variety of downstream targets. This function infers the existence of MN subtypes matching the identity of the targets they innervate.
Nicolas eStifani
doaj   +5 more sources

A size principle for recruitment of Drosophila leg motor neurons

eLife, 2020
To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control ...
Anthony W Azevedo, Evyn S Dickinson, Pralaksha Gurung, Lalanti Venkatasubramanian, Richard S Mann, John C Tuthill   +5 more
doaj   +2 more sources

DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

Acta Neuropathologica Communications, 2020
DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, relationships between DNA damage accumulation, DNA damage response (DDR), and upper and lower motor neuron vulnerability in human ALS are unclear; furthermore ...
Byung Woo Kim, Ye Eun Jeong, Margaret Wong, Lee J. Martin   +3 more
doaj   +2 more sources

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development

Frontiers in Cellular Neuroscience, 2016
Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller, Heidi R Fuller, Berhan eMandefro, Berhan eMandefro, Sally L Shirran, Andrew R Gross, Anjoscha Samija Kaus, Catherine H Botting, Glenn E Morris, Glenn E Morris, Dhruv eSareen, Dhruv eSareen, Dhruv eSareen   +12 more
doaj   +2 more sources

Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization [PDF]

eLife
Sensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise connectivity, to transform sensation into compensatory behavior. Whether and how motor neuron populations specify the subtype fate and/or sensory connectivity of their pre-
Dena Goldblatt, Basak Rosti, Kyla Rose Hamling, Paige Leary, Harsh Panchal, Marlyn Li, Hannah Gelnaw, Stephanie Huang, Cheryl Quainoo, David Schoppik   +9 more
doaj   +2 more sources

Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons

Nature, 2019
There is increased appreciation that dopamine neurons in the midbrain respond not only to reward1 and reward-predicting cues1,2, but also to other variables such as the distance to reward3, movements4–9 and behavioural choices10,11. An important question
Weston Fleming, Sue Ann Koay, Stephan Y Thiberge   +2 more
exaly   +2 more sources

Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes

eLife, 2023
Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels ...
Benjamin M Zemel, Alexander A Nevue, Leonardo ES Tavares, Andre Dagostin, Peter V Lovell, Dezhe Z Jin, Claudio V Mello, Henrique von Gersdorff   +7 more
doaj   +1 more source

Motor neurons in the escape response circuit of white shrimp (Litopenaeus setiferus) [PDF]

PeerJ, 2015
Many decapod crustaceans perform escape tailflips with a neural circuit involving giant interneurons, a specialized fast flexor motor giant (MoG) neuron, populations of larger, less specialized fast flexor motor neurons, and fast extensor motor neurons ...
Zen Faulkes
doaj   +2 more sources

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

Nature Neuroscience, 2020
The spinal cord is a fascinating structure that is responsible for coordinating movement in vertebrates. Spinal motor neurons control muscle activity by transmitting signals from the spinal cord to diverse peripheral targets.
Jacob A. Blum, Sandy L. Klemm, J. Shadrach, Kevin A. Guttenplan, Lisa Nakayama, Arwa S. Kathiria, Phuong Hoang, Olivia Gautier, Julia A. Kaltschmidt, W. Greenleaf, A. Gitler   +10 more
semanticscholar   +1 more source

Calcium imaging of CPG-evoked activity in efferent neurons of the stick insect. [PDF]

PLoS ONE, 2018
The stick insect is a well-established experimental animal to study the neural basis of walking. Here, we introduce a preparation that allows combining calcium imaging in efferent neurons with electrophysiological recordings of motor neuron activity in ...
Jens Goldammer, Charalampos Mantziaris, Ansgar Büschges, Joachim Schmidt   +3 more
doaj   +1 more source