Results 1 to 10 of about 2,514,411 (397)

Motor neurons and the generation of spinal motor neurons diversity [PDF]

Frontiers in Cellular Neuroscience, 2014
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS) controlling a variety of downstream targets. This function infers the existence of MN subtypes matching the identity of the targets they innervate.
Nicolas eStifani
doaj   +4 more sources

A size principle for recruitment of Drosophila leg motor neurons

eLife, 2020
To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control ...
Anthony W Azevedo, Evyn S Dickinson, Pralaksha Gurung, Lalanti Venkatasubramanian, Richard S Mann, John C Tuthill   +5 more
doaj   +2 more sources

Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. [PDF]

PLoS ONE, 2012
Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons.
Sophie R Thomson, Joya E Nahon, Chantal A Mutsaers, Derek Thomson, Gillian Hamilton, Simon H Parson, Thomas H Gillingwater   +6 more
doaj   +13 more sources

DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

Acta Neuropathologica Communications, 2020
DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, relationships between DNA damage accumulation, DNA damage response (DDR), and upper and lower motor neuron vulnerability in human ALS are unclear; furthermore ...
Byung Woo Kim, Ye Eun Jeong, Margaret Wong, Lee J. Martin   +3 more
doaj   +2 more sources

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development

Frontiers in Cellular Neuroscience, 2016
Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller, Heidi R Fuller, Berhan eMandefro, Berhan eMandefro, Sally L Shirran, Andrew R Gross, Anjoscha Samija Kaus, Catherine H Botting, Glenn E Morris, Glenn E Morris, Dhruv eSareen, Dhruv eSareen, Dhruv eSareen   +12 more
doaj   +2 more sources

GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila [PDF]

G3: Genes, Genomes, Genetics, 2019
The Drosophila melanogaster larval neuromuscular system is extensively used by researchers to study neuronal cell biology, and Drosophila glutamatergic motor neurons have become a major model system.
Juan J. Pérez-Moreno, Cahir J. O’Kane
doaj   +2 more sources

Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures. [PDF]

PLoS ONE, 2014
Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death.
Nuno Jorge Lamas, Bethany Johnson-Kerner, Laurent Roybon, Yoon A Kim, Alejandro Garcia-Diaz, Hynek Wichterle, Christopher E Henderson   +6 more
doaj   +5 more sources

Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS

iScience, 2021
Summary: The neuromuscular junction is a synapse critical for muscle strength and coordinated motor function. Unlike CNS injuries, motor neurons mount robust regenerative responses after peripheral nerve injuries.
Jennifer L. Shadrach, Wesley M. Stansberry, Allison M. Milen, Rachel E. Ives, Elizabeth A. Fogarty, Anthony Antonellis, Brian A. Pierchala   +6 more
doaj   +1 more source

Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes

eLife, 2023
Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels ...
Benjamin M Zemel, Alexander A Nevue, Leonardo ES Tavares, Andre Dagostin, Peter V Lovell, Dezhe Z Jin, Claudio V Mello, Henrique von Gersdorff   +7 more
doaj   +1 more source

Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. [PDF]

, 2020
In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation.
A Espana, A Espana, A Gow, A Harris, A Roy, A Wilzen, AE Talpalar, AF Ribeiro Jr., C Francius, C Landry, DC Lu, E Audouard, E Audouard, E Palmesino, F Clotman, F Clotman, FJ Stam, FP Lemaigre, HS Rhee, I Laudadio, J Cai, KU Kabayiza, L Landmesser, L Landmesser, M Sander, M Toch, M Zuchner, NR Lorente De, O Kjaerulff, P Jacquemin, P Jacquemin, P Whelan, S Velasco, TM Jessell, V Vanhorenbeeck, VJ Lannoy, W Wang   +36 more
core   +1 more source