Results 41 to 50 of about 552,175 (353)
Prepontine non-giant neurons drive flexible escape behavior in zebrafish [PDF]
, 2019 Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level.
Bergeron, S. +4 more
core +2 more sources
Visuomotor Transformation in the Fly Gaze Stabilization System [PDF]
, 2008 For sensory signals to control an animal's behavior, they must first be transformed into a format appropriate for use by its motor systems. This fundamental problem is faced by all animals, including humans.
Holger G Krapp +2 more
core +9 more sources
Frontiers in Cellular Neuroscience, 2016 Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller +12 more
doaj +1 more source
Acta Neuropathologica Communications, 2020 DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, relationships between DNA damage accumulation, DNA damage response (DDR), and upper and lower motor neuron vulnerability in human ALS are unclear; furthermore ...
Byung Woo Kim +3 more
doaj +1 more source
Neurobiology of Disease, 2012 In amyotrophic lateral sclerosis (ALS) some motor neurons degenerate while others survive. The molecular mechanisms underlying this selective vulnerability and resistance, respectively, are poorly understood.
Cornelia Ringer +2 more
doaj +1 more source
Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
Cell Reports, 2023 Summary: Dysregulated neuronal excitability is a hallmark of amyotrophic lateral sclerosis (ALS). We sought to investigate how functional changes to the axon initial segment (AIS), the site of action potential generation, could impact neuronal ...
Peter Harley +9 more
doaj +1 more source
TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death [PDF]
, 1997 Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Soledad Alcántara +5 more
openalex +3 more sources
A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [PDF]
, 2011 The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based transport to deliver essential cargo into dendrites.
Goldstein, Lawrence SB +3 more
core +2 more sources
Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons. [PDF]
PLoS ONE, 2012 TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase ...
Takuto Hideyama +4 more
doaj +1 more source
State Variables of the Arm May Be Encoded by Single Neuron Activity in the Monkey Motor Cortex [PDF]
, 2016 Revealing the type of information encoded by neurons activity in the motor cortex is essential not only for understanding the mechanism of motion control but also for developing a brain-machine interface.
Eizo Miyashita, Yutaka Sakaguchi
core +2 more sources