Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A mechanochemical model of the forward/backward movement of motor protein kinesin-1. [PDF]
J Biol Chem, 2022 Shen B, Zhang Y.
europepmc +1 more source
Motor Neuron Cell Death in Wobbler Mutant Mice Follows Overexpression of the G-protein-coupled, Protease-activated Receptor for Thrombin [PDF]
, 2000 Barry W. Festoff +5 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Kinesin-13, a Motor Protein, is Regulated by Polo-like Kinase in Giardia lamblia. [PDF]
Korean J Parasitol, 2022 Park EA, Kim J, Shin MY, Park SJ.
europepmc +1 more source
Depletion of a Microtubule-Associated Motor Protein Induces the Loss of Dendritic Identity [PDF]
, 2000 Wenqian Yu +5 more
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
FtsK, a DNA Motor Protein, Coordinates the Genome Segregation and Early Cell Division Processes in Deinococcus radiodurans. [PDF]
mBio, 2022 Mishra S, Misra HS, Kota S.
europepmc +1 more source
Motor protein independent binding of endocytic carrier vesicles to microtubules in vitro.
, 1991 John R. Scheel, T E Kreis
openalex +1 more source
The Survival Motor Neuron Protein of Schizosacharomyces pombe [PDF]
, 2000 Sergey Paushkin +5 more
openalex +1 more source