The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins. [PDF]
J Biol Chem, 2023 Soniat MM +3 more
europepmc +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Active spiralling of microtubules driven by kinesin motors
Scientific ReportsCytoskeletal filaments propelled by surface-bound motor proteins can be viewed as active polymers, a class of active matter. When constraints are imposed on their movements, the propelled cytoskeletal filaments show dynamic patterns distinct from ...
Douglas Kagoiya Ng’ang’a +3 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Breaking the clip for cargo unloading from motor proteins: mechanism and significance. [PDF]
Microb Cell, 2022 Obara K, Kamura T.
europepmc +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Army motor maintenance: inspection of motor vehicles, volume II, chapter 32.
, 2008 Officers in command of Motor Transport companies and other organizations operating motor vehicles are responsible that all vehicles are maintained in a proper state of mechanical efficiency.
Quartermaster Motor Transport School
core
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior. [PDF]
Front Cell Dev Biol, 2021 Yadav S, Kunwar A.
europepmc +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source