Results 201 to 210 of about 498,521 (337)

A Unified Walking Model for Dimeric Motor Proteins. [PDF]

Biophys J, 2018
Sasaki K, Kaya M, Higuchi H.
europepmc   +1 more source

Author response: Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10

, 2019
Lalanti Venkatasubramanian, Zhenhao Guo, Shuwa Xu, Liming Tan, Qi Xiao, Sonal Nagarkar-Jaiswal, Richard S. Mann   +6 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins. [PDF]

Proc Natl Acad Sci U S A, 2019
Hwang W, Karplus M.
europepmc   +1 more source

MOESM11 of Salivary gland proteome analysis of developing adult female Haemaphysalis longicornis ticks: molecular motor and TCA cycle-related proteins play an important role throughout development

, 2019
Shuguang Ren, Baowen Zhang, Xiaomin Xue, Xiaoshuang Wang, Huaqu Zhao, Xiaoli Zhang, Minjing Wang, Qi Xiao, Hui Wang, Jingze Liu   +9 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Molecular switch-like regulation in motor proteins. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2018
Tafoya S, Bustamante C.
europepmc   +1 more source

Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants [PDF]

, 2019
Franca Vulinović, Victor Krajka, Torben J. Hausrat, Philip Seibler, Daniel Alvarez‐Fischer, Harutyun Madoev, Jin‐Sung Park, Kishore R. Kumar, Carolyn M. Sue, Katja Lohmann, Matthias Kneussel, Christine Klein, Aleksandar Raković   +12 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

The cytoskeletal motor proteins Dynein and MyoV direct apical transport of Crumbs.

Dev Biol, 2020
Aguilar-Aragon M, Fletcher G, Thompson BJ.   +2 more
europepmc   +1 more source