Results 61 to 70 of about 830,352 (306)

Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish

International Journal of Molecular Sciences, 2023
DJ-1 is a redox sensitive protein with a wide range of functions related to oxidative stress protection. Mutations in the park7 gene, which codes for DJ-1 are associated with early onset familial Parkinson’s disease and increased astrocytic DJ-1 levels are found in pathologic tissues from idiopathic Parkinson’s disease. We have previously established a
Lakshmi Chavali, Ingeborg Yddal, Ersilia Bifulco, Simen Mannsåker, Dagne Røise, Jack Law, Ann-Kristin Frøyset, Sushma Grellscheid, Kari Fladmark   +8 more
openaire   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Alexithymia and apathy in Parkinson's disease: neurocognitive correlates [PDF]

, 2013
Non-motor symptoms such as neuropsychiatric and cognitive dysfunction have been found to be common in Parkinson’s disease (PD) but the relation between such symptoms is poorly understood.
Bogdanova, Yelena, Cronin-Golomb, A.
core   +2 more sources

Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease [PDF]

Biomolecules, 2021
Parkinson’s disease (PD) usually presents in older adults and typically has both motor and non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from dopaminergic neuronal cell loss in the mid-brain substantia nigra pars compacta region.
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Lipopolysaccharide animal models of Parkinson’s disease: Recent progress and relevance to clinical disease

Brain, Behavior, & Immunity - Health, 2020
Parkinson’s disease (PD) is one of the most common neurodegenerative movement disorders which is characterised neuropathologically by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies ...
Isaac Deng, Frances Corrigan, Guangxi Zhai, Xin-Fu Zhou, Larisa Bobrovskaya   +4 more
doaj   +1 more source

Detection of emotions in Parkinson's disease using higher order spectral features from brain's electrical activity [PDF]

, 2014
Non-motor symptoms in Parkinson's disease (PD) involving cognition and emotion have been progressively receiving more attention in recent times. Electroencephalogram (EEG) signals, being an activity of central nervous system, can reflect the underlying ...
Aftanas, Ariatti, Balconi, Balli, Baumgartner, Beck, Bouchard, Bowers, Bradley, Brown, Christianini, Chua, Clark, Cohen, Dara, Davidson, Fahn, Folstein, Gao, Garrido-Vásquez, Gray, Gross, Hadjidimitriou, Hamdi, Han, Hoehn, Hsu, Janvin, Jeong, Jerritta, Kawamura, Kenneth Sundaraj, Kessous, Khairiyah Mohamad, Kim, Kim, Klimesch, Kober, Lang, Lawrence, Lima, M. Murugappan, McCarthy, Mikels, Miller, Mohd Iqbal Omar, Mohr, Muller, Murugappan, Nikias, Norlinah Mohamed Ibrahim, Oathes, Oldfield, Park, Paulmann, Pell, Petrantonakis, Pillon, Péron, R. Palaniappan, R. Yuvaraj, Redondo, Roschke, Sammler, Savitt, Schmidt, Schröder, Shen, Sprengelmeyer, Stama, Suzuki, Tessitore, Wang, Wang, Wieser, Wieser, Yuvaraj   +76 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Zinc containing dental fixative causing copper deficiency myelopathy [PDF]

, 2017
A 62-year-old male, previously well, was referred to neurology clinic following 6 months history of worsening lower limbs instability, paraesthesia, pain and weakness rendering him housebound.
Abdul-Rahim, Azmil H., Carroll, Liam Stuart, Murray, Rosanne   +2 more
core   +1 more source