Results 81 to 90 of about 2,858,985 (262)

Toward future diagnostics of Parkinson's disease: a perspective on multimodal motor assessment and personalized digital twins

Frontiers in Aging Neuroscience
The accurate diagnosis of Parkinson's disease (PD) remains challenging due to the heterogeneity of motor symptoms and the reliance on subjective clinical assessments. Although biomarkers such as dopaminergic imaging, fluid assays, and genetic testing can
Júlia Rey Vilches, Sadasivan Puthusserypady, Bo Biering-Sørensen, Bo Biering-Sørensen, Trine Hørmann Thomsen, Trine Hørmann Thomsen, Silvia Tolu   +6 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Effectiveness and applications of neurologic music therapy in motor and non-motor rehabilitation for older adults with Parkinson’s disease: a systematic review and meta-analysis

Frontiers in Neurology
PurposeTo systematically assess the current status and effectiveness of neurologic music therapy in the rehabilitation of older adults with Parkinson’s disease.Materials and methodsA comprehensive search was conducted for randomized controlled trials ...
Aoyi Li, Yiyao Yang, Qiyu Jiang, Tiantian Wu, Tiantian Li   +4 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Non-motor Symptoms of Parkinson's Disease

, 2007
SUMMARYIn addition to the typical motor symptoms (resting tremor, cogwheel rigidity, bradykinesia, postural instability) of Parkinson's disease (PD), non-motor symptoms are sources of considerable burden in people with PD, espe-cially in elderly patients.
Eugene C Lai, Jyh-Gong Gabriel Hou
core   +1 more source

Gender discrepancies and differences in motor and non-motor symptoms, cognition, and psychological outcomes in the treatment of Parkinson’s disease with subthalamic deep brain stimulation

Frontiers in Neurology
Available data suggest that there may be gender differences in the effect of STN-DBS in the treatment of Parkinson’s disease (PD). The aim of this study was to review data on gender discrepancies and gender differences in clinical outcomes in PD patients
Martijn Hendriks, Martijn Hendriks, Ruben Saman Vinke, Dejan Georgiev, Dejan Georgiev   +4 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

[Non-motor symptoms of Parkinson's disease]

, 2012
Contains fulltext : 110284.pdf (Publisher’s version ) (Closed access)Parkinson's disease has traditionally been viewed as a disease with only motor features.
Nijhof, A., Weerkamp, N.J., Tissingh, G.
core  

RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION [PDF]

, 2013
Parkinson’s disease (PD) is a progressive debilitating neurodegenerative disorder characterized by resting tremor, rigidity, bradykinesia and postural instability. As the disease progresses there is a loss of dopamine (DA) neurons in the substantia nigra
Subramanian, Krishna
core  

Drug discovery and development for Parkinson’s disease: are preclinical models good enough?

Frontiers in Aging Neuroscience
Parkinson’s disease (PD) remains a major challenge for translational neuroscience, with an increasing global prevalence and persistent unmet therapeutic needs.
Alejandro Reinares-Sebastián, Alejandro Reinares-Sebastián, Alejandro Reinares-Sebastián, Noelia Esteban-García, Noelia Esteban-García, Noelia Esteban-García, Masahiko Takada, Masahiko Takada, Inés Trigo-Damas, Inés Trigo-Damas, Inés Trigo-Damas, Inés Trigo-Damas   +11 more
doaj   +1 more source