Results 91 to 100 of about 2,858,985 (262)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review

Dementia & Neuropsychologia
Deep brain stimulator (DBS) implant surgery is considered a breakthrough in the treatment of Parkinson's disease, especially in cases where motor symptoms cannot be controlled through conventional drug treatment.
Flavia Amaral Machado, Caroline Tozzi Reppold   +1 more
doaj   +1 more source

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Neuropsychiatric Disease and Treatment, 2021
Yu Cao,1,* Gongfeng Li,1,* Jinsheng Xue,2,* Guijuan Zhang,1 Sensen Gao,1 Yuling Huang,1 Aiqin Zhu1 1Institute of Geriatric, Qinghai Provincial People’s Hospital, Xining, People’s Republic of China; 2Foreign Cooperation Office, Chengdu Fifth ...
Cao Y, Li G, Xue J, Zhang G, Gao S, Huang Y, Zhu A   +6 more
doaj  

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Association between fatigue and other motor and non-motor symptoms in Parkinson’s disease patients

, 2014
Although fatigue is a common non-motor symptom in patients affected by Parkinson's disease (PD), its association with motor and other non-motor symptoms is still largely unclear.
Perra S., Solla P., Corona A., Marrosu F., Cannas A., Bassareo P. P., Mulas C. S., Perra, Silvia, Corona, Andrea, Bassareo, Pier Paolo, Mulas, Cesare Salvatore, Cannas, Antonino, Solla, Paolo, Marrosu, Francesco   +13 more
core   +2 more sources

Influence of Age on the Effectiveness of Lee Silverman Voice Treatment^® BIG in Patients with Parkinson’s Disease: A Retrospective Exploratory Observational Study

Geriatrics
Background/Objectives: Advanced age in Parkinson’s disease (PD) is linked to worse motor function, more severe symptoms, and impaired activities of daily living (ADLs).
Masanobu Iwai, Kazuya Takeda, Soichiro Koyama, Ikuo Motoya, Yuichi Hirakawa, Hiroaki Sakurai, Yoshikiyo Kanada, Nobutoshi Kawamura, Mami Kawamura, Shigeo Tanabe   +9 more
doaj   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Non-motor symptoms: identification and management

, 2007
Non-motor symptoms are an important part of Parkinson's disease (PD) symptoms complex. They cause a significant burden on the quality of life of patients and their carers and remain a major cause of hospitalisation. Treatment of non-motor symptoms can be
Contrafatto, Donatella, Muzerengi, Sharon, Chaudhuri, K Ray   +2 more
core   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit

<jats:title>Abstract</jats:title><jats:p>Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc).
Al-kuraishy, Hayder M., Alharbi, Bandar, Alexiou, Athanasios, Al-Gareeb, Ali I., Alharbi, Hind, Papadakis, Marios, Elekhnawy, Engy, Batiha, Gaber El-Saber   +7 more
core   +2 more sources