Results 111 to 120 of about 830,352 (306)
Drug discovery and development for Parkinson’s disease: are preclinical models good enough?
Frontiers in Aging NeuroscienceParkinson’s disease (PD) remains a major challenge for translational neuroscience, with an increasing global prevalence and persistent unmet therapeutic needs.
Alejandro Reinares-Sebastián +11 more
doaj +1 more source
Neurobiology of dyslexia : A reinterpretation of the data [PDF]
, 2004 Theories of developmental dyslexia differ on how to best interpret the great variety of symptoms (linguistic, sensory, motor) observed in dyslexic individuals. One approach views dyslexia as a specific phonological deficit, which sometimes co-occurs with
Ramus, Franck
core +4 more sources
Piribedil for the Treatment of Motor and Non-motor Symptoms of Parkinson Disease
CNS Drugs, 2016 Dopamine agonists are well-established symptomatic medications for treating early and advanced Parkinson disease (PD). Piribedil was one of the first agonists to be marketed (1969) and is widely used as an extended-release oral formulation in European, Latin-American, and Asian countries.
Pérez Lloret, Santiago, Rascol, Olivier
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Frontiers in NutritionBackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. A growing body of evidence shows that a healthy diet, including the Mediterranean diet (MeDi), can slow the disease progression and improve ...
Jevgenija Guk +3 more
doaj +1 more source
Corticobasal syndrome: neuroimaging and neurophysiological advances [PDF]
, 2019 Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R-tau protein deposition in several brain regions that clinically manifests itself as a heterogeneous atypical parkinsonism typically expressing in the adulthood.
Asci, Francesco +9 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Applied SciencesIn individuals with Parkinson’s disease (PD), bradykinesia severity is related to physical activity (PA) inside homes. We aimed to investigate the effectiveness of the Lee Silverman Voice Treatment (LSVT)® BIG intervention in increasing at-home PA in ...
Yuichi Hirakawa +9 more
doaj +1 more source
Subregional 6-[18F]fluoro-ʟ-m-tyrosine Uptake in the Striatum in Parkinson's Disease [PDF]
, 2011 Background In idiopathic Parkinson's disease (PD) the clinical features are heterogeneous and include different predominant symptoms. The aim of the present study was to determine the relationship between subregional aromatic l-amino acid decarboxylase ...
Sayaka Asari +5 more
core +1 more source
Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt +5 more
wiley +1 more source