Results 121 to 130 of about 830,352 (306)

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Toward future diagnostics of Parkinson's disease: a perspective on multimodal motor assessment and personalized digital twins

Frontiers in Aging Neuroscience
The accurate diagnosis of Parkinson's disease (PD) remains challenging due to the heterogeneity of motor symptoms and the reliance on subjective clinical assessments. Although biomarkers such as dopaminergic imaging, fluid assays, and genetic testing can
Júlia Rey Vilches, Sadasivan Puthusserypady, Bo Biering-Sørensen, Bo Biering-Sørensen, Trine Hørmann Thomsen, Trine Hørmann Thomsen, Silvia Tolu   +6 more
doaj   +1 more source

Minimal clinically important difference of the EORTC QLQ-CIPN20 for worsening peripheral neuropathy in patients receiving neurotoxic chemotherapy. [PDF]

, 2019
Context/objectivesThis is the first study to determine the minimal clinically important difference (MCID) of the European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-CIPN twenty-item scale (EORTC QLQ-CIPN20), a ...
Ang, Emily, Au, Joseph SK, Bandla, Aishwarya, Chan, Alexandre, Chan, Choi Wan, Cheng, Hui Lin, Farrell, Carole, Leung, Kwun To, Li, Yu Chung, Loh, Kiley WJ, Lopez, Violeta, Molassiotis, Alex, Ng, Chiu Chin, Suen, Lorna, Sundar, Raghav, Wong, Kam-Hung, Yeo, Fiona, Yorke, Janelle   +17 more
core   +3 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Effectiveness and applications of neurologic music therapy in motor and non-motor rehabilitation for older adults with Parkinson’s disease: a systematic review and meta-analysis

Frontiers in Neurology
PurposeTo systematically assess the current status and effectiveness of neurologic music therapy in the rehabilitation of older adults with Parkinson’s disease.Materials and methodsA comprehensive search was conducted for randomized controlled trials ...
Aoyi Li, Yiyao Yang, Qiyu Jiang, Tiantian Wu, Tiantian Li   +4 more
doaj   +1 more source

Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson\u2019s disease [PDF]

, 2018
Background: Pain is a common and undertreated non-motor symptom in patients with Parkinson\u2019s disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions.
Freo, Ulderico, Furnari, Maurizio, Ori, Carlo   +2 more
core  

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review

Dementia & Neuropsychologia
Deep brain stimulator (DBS) implant surgery is considered a breakthrough in the treatment of Parkinson's disease, especially in cases where motor symptoms cannot be controlled through conventional drug treatment.
Flavia Amaral Machado, Caroline Tozzi Reppold   +1 more
doaj   +1 more source

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Neuropsychiatric Disease and Treatment, 2021
Yu Cao,1,* Gongfeng Li,1,* Jinsheng Xue,2,* Guijuan Zhang,1 Sensen Gao,1 Yuling Huang,1 Aiqin Zhu1 1Institute of Geriatric, Qinghai Provincial People’s Hospital, Xining, People’s Republic of China; 2Foreign Cooperation Office, Chengdu Fifth ...
Cao Y, Li G, Xue J, Zhang G, Gao S, Huang Y, Zhu A   +6 more
doaj  

Non-Dopaminergic Drugs for Motor Symptoms

, 2012
A new optimism that Parkinson's disease can be defeated is energizing the research community. Halting the progression of the disease, restoring function, and even prevention are all realistic goals. This comprehensive volume provides state-of-the-art information on all aspects of Parkinson's disease, including epidemiology, genetics, diagnosis ...
Burkhard, Pierre, Vingerhoets, François
openaire   +2 more sources