Results 61 to 70 of about 4,395,352 (325)

Mouse MRI shows brain areas relatively larger in males emerge before those larger in females

Nature Communications, 2018
Sex differences occur in various aspects of neurodevelopment. Here the authors use manganese-enhanced MRI at nine different postnatal stages to detail the development of structural sex differences in the mouse brain.
Lily R. Qiu, Darren J. Fernandes, Kamila U. Szulc-Lerch, Jun Dazai, Brian J. Nieman, Daniel H. Turnbull, Jane A. Foster, Mark R. Palmert, Jason P. Lerch   +8 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Brocker, Thomas, Hubele, S., Lane, P., Lanzavecchia, A., McConnell, F., Padovan, E.   +5 more
core   +1 more source

Effect of Shipping on the Microbiome of Donor Mice Used to Reconstitute Germ-Free Recipients

Gut Microbes Reports
The gut microbiome (GM) influences multiple processes during host development and maintenance. To study these events, fecal microbiota transfer (FMT) to germ-free (GF) recipients is often performed.
Zachary L. McAdams, Jared Yates, Giedre Turner, Rebecca A. Dorfmeyer, Mary Wight-Carter, James Amos-Landgraf, Craig L. Franklin, Aaron C. Ericsson   +7 more
doaj   +1 more source

Acetylated tubulin is essential for touch sensation in mice

eLife, 2016
At its most fundamental level, touch sensation requires the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating electro-chemical signals.
Shane J Morley, Yanmei Qi, Loredana Iovino, Laura Andolfi, Da Guo, Nereo Kalebic, Laura Castaldi, Christian Tischer, Carla Portulano, Giulia Bolasco, Kalyanee Shirlekar, Claudia M Fusco, Antonino Asaro, Federica Fermani, Mayya Sundukova, Ulf Matti, Luc Reymond, Adele De Ninno, Luca Businaro, Kai Johnsson, Marco Lazzarino, Jonas Ries, Yannick Schwab, Jing Hu, Paul A Heppenstall   +24 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

EFEK ANALGETIK SARI RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) PADA TIKUS PUTIH (Rattus norvegicus) STRAIN WISTAR [PDF]

, 2009
Painful is inconvenience feeling which felt by patient, so that the sigh represent symptom and sign which not too difficult recognized by klinis but its vary cause (Soelistiono, 2004). Painful if body organ, muscle, or skin injure by, disease, have cram,
WIDYASARI SUTRISNA, YUNIA
core  

Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant

Cell Death and Disease, 2023
Pathogenic variants in BRCA2 are known to significantly increase the lifetime risk of developing breast and ovarian cancers. Sequencing-based genetic testing has resulted in the identification of thousands of BRCA2 variants that are considered to be ...
Arun Prakash Mishra, Suzanne Hartford, Rajani Kant Chittela, Sounak Sahu, Suhas S. Kharat, Lucia Alvaro-Aranda, Aida Contreras-Perez, Teresa Sullivan, Betty K. Martin, Mary Albaugh, Eileen Southon, Sandra Burkett, Baktiar Karim, Aura Carreira, Lino Tessarollo, Shyam K. Sharan   +15 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Abrogation of Rb Tumor Suppression Initiates GBM in Differentiated Astrocytes by Driving a Progenitor Cell Program

Frontiers in Oncology, 2022
Glioblastoma (GBM) remains lethal with no effective treatments. Despite the comprehensive identification of commonly perturbed molecular pathways, little is known about the disease’s etiology, particularly in early stages.
Amit S. Adhikari, Teresa Sullivan, Rhishikesh Bargaje, Lucy Lu, T Norene O’Sullivan, Yurong Song, Terry Van Dyke   +6 more
doaj   +1 more source