Results 141 to 150 of about 61,960 (179)

Selective amplification of mouse mammary tumor virus in mammary tumors of GR mice

Journal of Virology, 1980
DNAs extracted from the mammary tumors of GR mice were analyzed for mouse mammary tumor virus proviral sequences by the restriction enzyme-Southern blot procedure. The tumor DNAs contain more proviral copies of mouse mammary tumor virus than DNA from a nonmalignant tissue. The degree of proviral amplification is small (ca. one to five additional copies)
T G, Fanning, J P, Puma, R D, Cardiff
openaire   +2 more sources

Breast Cancer and Mouse Mammary Tumor Virus

Annals of Internal Medicine, 1983
Excerpt To the editor: The recent report by Poon and associates (1) provides additional evidence associating antigens of mouse mammary tumor virus with human breast cancer.
openaire   +2 more sources

Quantification of mouse mammary tumor virus structural proteins in hormone‐induced mammary tumors of low mammary tumor mouse strains

International Journal of Cancer, 1980
AbstractThe expression of the mouse mammary tumor virus (MMTV) in hormone‐induced mammary tumors was investigated by means of a radioimmunoassay for two major MMTV proteins, gp52 and p27. MMTV proteins were isolated on lectin affinity‐ and ion‐exchange chromatography columns. The purified viral proteins were electrophoretically homogeneous and retained
Nusse, R, Michalides, R, Boot, L M, Ropcke, G   +3 more
openaire   +2 more sources

Gene order of the mouse mammary tumor virus glycoproteins

Virology, 1977
Immunochemical and tryptic peptide mapping techniques were used to show that the mouse mammary tumor virus (MMTV) envelope glycoproteins gp52 and gp36 are distinct components derived from a common glycosylated precursor polypeptide of 75,000 daltons (gPr75). Because both gp52 and gp36 are derived from a common precursor polypeptide and therefore have a
G, Schochetman, S, Oroszlan, L, Arthur, D, Fine   +3 more
openaire   +2 more sources

Mouse mammary tumor virus as a model for viral carcinogenesis

Journal of Toxicology and Environmental Health, 1976
Evidence is presented suggesting that genetic control may be the limiting factor in mammary tumor virus (MTV) positive mammary oncogenesis. Studies with hybrid mice involving high and low MTV-expressing murine strains suggest that expression of MTV in milk may not be as important in tumorigenesis as previously thought.
openaire   +2 more sources

Mouse Mammary Tumor Virus and Cancer

2011
The retrovirus mouse mammary tumor virus (MMTV) was discovered in the 1930s as a milk-transmitted agent that causes breast cancer in mice. MMTV causes mammary tumors by insertional activation or mutation of cellular oncogenes. Some of the oncogenes activated by MMTV insertion have been also associated with human breast cancer.
openaire   +1 more source

Heterogeneity of expression and induction of mouse mammary tumor virus antigens in mouse mammary tumors.

Cancer research, 1982
Seven spontaneous BALB/cfC3H mouse mammary tumors were heterogeneous in expression of murine mammary tumor virus-associated cell surface antigens. To determine the basis of this heterogeneity, cells from spontaneous tumors and from five subpopulations isolated from a single spontaneous tumor were examined for expression of viral antigens under both ...
Hager, J C, Heppner, G H
openaire   +1 more source

Mouse mammary tumor virus retropepsin

2004
Luis Menéndez-Arias, József Tözsér, Stephen Oroszlan   +2 more
openaire   +1 more source

Mouse Mammary Tumor Virus Expression and Mammary Tumor Development

1983
R, Michalides, A, van Ooyen, R, Nusse
openaire   +2 more sources

Molecular Aspects of Mouse Mammary Tumor Virus Biology

1987
Publisher Summary This chapter outlines the structure and replication of the mouse mammary tumor virus (MMTV), and elaborates those aspects of MMTV molecular biology that have provided an insight into the understanding of gene regulation and virally induced carcinogenesis.
openaire   +2 more sources