Results 71 to 80 of about 96,662 (219)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang   +10 more
wiley   +1 more source

Isolation of a Human Betaretrovirus from Patients with Primary Biliary Cholangitis

Viruses, 2022
A human betaretrovirus (HBRV) has been linked with the autoimmune liver disease, primary biliary cholangitis (PBC), and various cancers, including breast cancer and lymphoma.
Mariam Goubran, Weiwei Wang, Stanislav Indik, Alexander Faschinger, Shawn T. Wasilenko, Jasper Bintner, Eric J. Carpenter, Guangzhi Zhang, Paulo Nuin, Georgina Macintyre, Gane K.-S. Wong, Andrew L. Mason   +11 more
doaj   +1 more source

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss [PDF]

, 2015
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers.
Akerman, M., Arun, G., Brogi, E., Chang, K. C., Diermeier, S., Egeblad, M., Hearn, S., Kim, Y., Krainer, A. R., MacLeod, A. R., Norton, L., Spector, D. L., Wilkinson, J. E.   +12 more
core   +1 more source

In Vitro Production of Mouse Mammary Tumor Virus in a Mouse Mammary Tumor Ascites Line [PDF]

Proceedings of the National Academy of Sciences, 1973
An ascites line derived from a spontaneous mouse mammary carcinoma produces, on explantation and cultivation in vitro , large amounts of oncornavirus particles. The biochemical, biophysical, and electron microscopic characteristics of the virions are described.
Keydar, J, Gilead, Z, Hartman, J R, Ben, shaul Y   +3 more
openaire   +2 more sources

Dmp1α inhibits HER2/neu-induced mammary tumorigenesis. [PDF]

PLoS ONE, 2013
Our recent study shows a pivotal role of Dmp1 in quenching hyperproliferative signals from HER2 to the Arf-p53 pathway as a safety mechanism to prevent breast carcinogenesis.
Elizabeth A Fry, Pankaj Taneja, Dejan Maglic, Sinan Zhu, Guangchao Sui, Kazushi Inoue   +5 more
doaj   +1 more source

Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

Cell Reports, 2021
Summary: MED1 (mediator subunit 1) co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice.
Yongguang Yang, Marissa Leonard, Zhenhua Luo, Syn Yeo, Gregory Bick, Mingang Hao, Chunmiao Cai, Mahmoud Charif, Jiang Wang, Jun-Lin Guan, Elyse E. Lower, Xiaoting Zhang   +11 more
doaj   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis

Neoplasia: An International Journal for Oncology Research, 2017
RCAS avian viruses have been used to deliver oncogene expression and induce tumors in transgenic mice expressing the virus receptor TVA. Here we report the generation and characterization of a novel RCAS-Cre-IRES-PyMT (RCI-PyMT) virus designed to ...
Wei Wang, Yanling Meng, Bingning Dong, Jie Dong, Michael M. Ittmann, Chad J. Creighton, Yang Lu, Hong Zhang, Tao Shen, Jianghua Wang, David R. Rowley, Yi Li, Fengju Chen, David D. Moore, Feng Yang   +14 more
doaj   +1 more source