Results 91 to 100 of about 61,960 (179)

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković   +6 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang   +9 more
wiley   +1 more source

Machine Learning of Personal Repertoires From Public T Cell Receptors

open access: yesImmunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT The T‐cell receptor (TCR) repertoire records an individual's immunological history, but most unique CDR3 sequences in any one person are private and uninformative about anyone else. A small subset, however, recurs predictably across unrelated donors.
Or Malca, Alona Zilberberg, Sol Efroni
wiley   +1 more source

Molecular characterization of human papillomavirus and mouse mammary tumor virus-like infections in prostate cancer tissue and relevance with tumor characteristics. [PDF]

open access: yesMol Clin Oncol, 2022
Abumsimir B   +9 more
europepmc   +1 more source

The Role Of Mouse Mammary Tumor Virus In The Induction And Progression Of Mouse Mammary Tumors [PDF]

open access: yes, 1986
Mouse mammary tumor virus (MMTV) is a retrovirus which causes mammary tumors in many strains of mice. An essential part of the viral life cycle involves the integration of a double-stranded DNA provirus into the host cell genome. Tumorigenesis is thought to be mediated by such integrated proviruses.;Restriction endonuclease analysis of the DNA from a ...
openaire  

A purine loop and the primer binding site are critical for the selective encapsidation of mouse mammary tumor virus genomic RNA by Pr77Gag. [PDF]

open access: yesNucleic Acids Res, 2021
Chameettachal A   +9 more
europepmc   +1 more source

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