Results 71 to 80 of about 61,960 (179)

Stress‐Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis

Small, EarlyView.
Granular hydrogels are developed to tune the yield stress levels at which 3D tissue culture matrices undergo plastic deformation. We use these materials to regulate growth‐induced stresses, with demonstrable effects on cancer spheroid invasion and brain organoid morphogenesis.
James P. W. Reeves, Sabra Rostami, Mostafa Rammal, Andrei Bocan, Paula Lépine, Matthew J. Harrington, Thomas M. Durcan, Christopher Moraes   +7 more
wiley   +1 more source

Exacerbated metastatic disease in a mouse mammary tumor model following latent gammaherpesvirus infection

Infectious Agents and Cancer, 2012
Background Controversy exists as to the ability of human gammaherpesviruses to cause or exacerbate breast cancer disease in patients. The difficulty in conducting definitive human studies can be overcome by investigating developing breast cancer in a ...
Chauhan Vinita S, Nelson Daniel A, Roy Lopamudra Das, Mukherjee Pinku, Bost Kenneth L   +4 more
doaj   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Cell‐Migration Visualization: Task Taxonomy, Systematic Review and Research Agenda

Computer Graphics Forum, EarlyView.
We present an expert‐validated task taxonomy for cell migration analysis and a PRISMA‐based systematic review that maps visualization tools to the tasks they support and the techniques they employ. This synthesis identifies current gaps and outlines opportunities for future research in cell migration visualization.
Ana Carla Correia, Thifany Souza, Ana Carolina Correia, Nivan Ferreira   +3 more
wiley   +1 more source

A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus

mBio, 2019
Complex human-pathogenic retroviruses cause high morbidity and mortality worldwide, but resist antiviral drugs and vaccine development due to evasion of the immune response.
Gurvani B. Singh, Hyewon Byun, Almas F. Ali, Frank Medina, Dennis Wylie, Haridha Shivram, Andrea K. Nash, Mary M. Lozano, Jaquelin P. Dudley   +8 more
doaj   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine

Frontiers in Immunology
IntroductionOncolytic vaccinia virus (VACV) strains are being investigated for use in immunotherapy as a new experimental cancer treatment. Here, we describe the construction, characterization, and use of VACV strains co-expressing murine Interleukin 2 ...
Mingyu Ye, Ivan Petrov, Ivaylo Gentschev, Eman M. Othman, Aladar A. Szalay, Aladar A. Szalay, Aladar A. Szalay   +6 more
doaj   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

Effects of BRCA1 Transgene Expression on Murine Mammary Gland Development and Mutagen-Induced Mammary Neoplasia

International Journal of Biological Sciences, 2007
To characterize the role of BRCA1 in mammary gland development and tumor suppression, a transgenic mouse model of BRCA1 overexpression was developed. Using the mouse mammary tumor virus (MMTV) promoter/enhancer, transgenic mice expressing human BRCA1 or ...
Arichika Hoshino, Cindy J. Yee, Mel Campbell, Randall L. Woltjer, Rebecca L. Townsend, Riet van der Meer, Yu Shyr, Jeffrey T. Holt, Harold L. Moses, Roy A. Jensen
doaj  

Comparison of Expression Profiles of Metastatic versus Primary Mammary Tumors in MMTV-Wnt-1 and MMTV-Neu Transgenic Mice

Neoplasia: An International Journal for Oncology Research, 2008
Distant metastases of human breast cancers have been suggested to be more different from each other than from their respective primary tumors, based on expression profiling.
Shixia Huang, Yidong Chen, Katrina Podsypanina, Yi Li   +3 more
doaj   +1 more source